What they say: Introduction:
A recent study from the Department of Genetics, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Harvard Medical School, Boston,USA; and Department of Pharmacology, School of Medicine, The University of New South Wales, Australia shows that Sirtuin-2 induces the checkpoint kinase BubR1 to increase lifespan. This study was published in the 1 July 2014 issue of the journal “EMBO” by Prof Sinclair, North BJ, and others.
What we say:
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product Lifespan extension therapy: Chlorogenic acid, found in coffee, green tea, brinjal, among others, increases life span via up-regulation of its target gene BubR1.
From Research Findings to Therapeutic Opportunity:
Chlorogenic acid, one of the constituents of Coffee, among others, as indicated below, extends mammalian lifespan via up-regulation of BuBR1
Green tea leaves
Chlorogenic acid/5-O-caffeoylquinic acid (CGA) , one of the constituents of Coffee, green tea, eggplant, peach, and prunes.
This study suggests a natural product-based life extension therapy.
Chlorogenic acid, by increasing the expression of its target gene, it may increase the expression of BuBR1. Thereby, it may: (1) delay diseases of aging; (2) slow down aging; and (3) prolong median life span. Thus, pharmacological formulations encompassing “Chlorogenic acid [5-O-caffeoylquinic acid (CGA)] or its analogs may be used to extend the lifespan of an individual.
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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Citation: Boominathan, Natural product Lifespan extension therapy: Chlorogenic acid, found in coffee, green tea, brinjal, among others, increases life span via up-regulation of its target gene BubR1, 3/November/2016, 7.23 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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Undisclosed information: How Chlorogenic acid increases the expression of BubR1 and extends mammalian life-span
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