Meformin aids in heart regeneration and promotes stress resistance: Metformin, the widely used drug in the treatment of T2DM, promotes heart regeneration and function and augments stress resistance against hypoxic stress through down regulation of p38-α, 8/January/2020, 1.58 pm
Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Significance: A number of studies suggest that Metformin, the widely used drug in the treatment of T2DM, protects against cardaic dysfunction; and increases lifespan of mammals. However the mechanistic basis of which remains largely elusive. This study suggests, for the first time, that Metformin, by suppressing the expression of […]
Little RNA can protect against cardiac dysfunction: LncRNA NEAT1-based Regenerative therapy for regaining the lost cardiomyocytes in Myocardial patients: LncRNA NEAT1 (Nuclear Enriched Abundant Transcript 1 (NEAT1) increases the expression of ERBB2/Her2 and promotes dedifferentiation of cardiomyocytes, via up-regulation of its target gene, 31/December/2019, 11.41 pm
Introduction: What they say A recent study from the Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel shows that “ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation.” This study was published, in the 6 April 2015 issue of the journal “Nature cell biology” (the number 1 journal in “Cell biology” research with an impact factor of 20+), by Prof Tzahor E, D’Uva E, and others. […]
Ascorbic acid-based regenerative cardiovascular therapy: Molecular mechanistic insight into how Vitamin C/Ascorbic acid protects against and promotes functional recovery after Myocardial Infarction: Vitamin C/Ascorbic acid(AA) inhibits DNA damage responses, induces telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte proliferation, regeneration and survival after myocardial infarction, via up-regulation of its target gene, 24/December/2019, 11.55 pm
What they say: A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published, in the 7 March 2013 issue of of the journal Nature, by Profs. Stefanie Dimmeler (Director, Center for Molecular Medicine), Reinier A Boon and others. What we say: On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief […]
Sauna (heat/thermal) therapy may safeguard your heart against cardiac dysfunction: Sauna (heat/thermal) therapy for cardiomyocyte proliferation and heart regeneration: Sauna (heat/thermal) therapy (at 41°C for 20 minutes) decreases tumor suppressor Mir-128 and cyclin-dependent kinase inhibitor p27 expression, increases SUZ12 expression, increases Cyclin E and CDK2 expression, promotes proliferation/re-entry of postnatal/adult cardiomyocytes, attenuates fibrosis, ameliorates cardiac dysfunction, and promotes heart repair in response to myocardial infarction, via up-regulation of its target gene, 17/December/2019, 7.14 am
Introduction: What they say: A recent study from Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, 45267, USA; Key Laboratory of Molecular Target and Clinical Pharmacology, School of Pharmaceutical Sciences & Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, 511436, China; and Department of Pathology and Laboratory Medicine, University […]
Polypill for Cardioprotection: Polypill-HAAE/HAAV-based therapy for Cardiac repair and myocardial infarction: A four-component Polypill-HAAE/HAAV consisting of Hydrochlorothiazide (12·5 mg), Aspirin (81 mg), Atorvastatin (20 mg), and Enalapril (5 mg) or Valsartan (40 mg) increases Agrin expression, activates Yap and ERK-mediated signaling, replaces scar tissue with functional cardiomyocytes, and promotes cardiomyocyte regeneration and repair after myocardial infarction, via up-regulation of its target gene, 25/September/2019, 8.45 pm
Introduction: What they say: A recent study from Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel; Department of Biomedical Engineering, Duke University, Durham, North Carolina 27708, USA; and Baylor College of Medicine and The Texas Heart Institute, Houston, Texas 77030, US shows that “The extracellular matrix protein Agrin promotes heart regeneration […]
Senolytics therapy for cardiac repair, cardiac regeneration and cardioprotection: Combinatorial therapy for postnatal Cardiomyocyte proliferation, repair and regeneration: A two-component Pill consisting of Dasatinib and Quercetin (Pill-DQ) decreases tumor suppressor MiR-128 and cyclin-dependent kinase inhibitor p27 expression, increases SUZ12 expression, increases Cyclin E and CDK2 expression, promotes proliferation/re-entry of postnatal/adult cardiomyocytes, attenuates fibrosis, ameliorates cardiac dysfunction, and promotes heart repair in response to myocardial infarction, via up-regulation of its target gene, 20/September/2019, 7.39 am
Introduction: What they say: A recent study from Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, 45267, USA; Key Laboratory of Molecular Target and Clinical Pharmacology, School of Pharmaceutical Sciences & Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, 511436, China; and Department of Pathology and Laboratory Medicine, University […]
