Diabetes

November 14, 2018

Astrocyte-derived neurotrophic factor comes to the rescue of Diabetes Mellitus: MANF (Mesencephalic astrocyte-derived neurotrophic factor) augments the expression of FGF19 and FGF1,  attenuates hepatic glucose production, decreases hepatic acetyl CoA content, brings down the levels of plasma ACTH, and corticosterone, augments insulin sensitivity, promotes weight loss and alleviates TIDM via upregulation of its target gene, 14/October/2018, 3.38 pm

Introduction: What they say  A study from Diabetes and Obesity Center of Excellence, Department of Medicine, University of Washington, Seattle, Washington, USA shows that Central injection […]
November 14, 2018

Molecular therapy for Regenerating the lost pancreatic β-cells in Diabetic patients: MANF (Mesencephalic astrocyte-derived neurotrophic factor)  increases the expression of IGF1R, INSR, and IRS2, and promotes an insulin-sensitized state via up-regulation of  its target gene Lin28, 14/November/2018, 3.11 pm

Introduction: What they say:   A study from the Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Boston Children’s Hospital and Dana-Farber Cancer Institute, Boston, Massachusetts, USA shows that “The Lin28/let-7 axis […]
October 25, 2018

Repurposing the anti-hypertensive agent Aliskiren into an anti-diabetic agent:  Aliskiren (brand name: Tekturna and Rasilez), an antihypertensive agent, increases the expression of IGF1R, INSR, and IRS2, and promotes an insulin-sensitized state, via up-regulation of  its target gene Lin28, 26/October, 2018, 12.15 am

Introduction: What they say:   A study from the Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Boston Children’s Hospital and Dana-Farber Cancer Institute, Boston, Massachusetts, USA shows that “The Lin28/let-7 axis […]
October 22, 2018

A musical way to stay free of diabetes: Music-based therapy for body weight control, energy homeostasis, and TIIDM: Music inhibits DNA methyltransferase 3a (Dnmt3a) expression, increases FGF21 expression, augments insulin sensitivity, increases glucose tolerance, and protects from diet-induced obesity and TIIDM, via up-regulation of its target gene, 22/September/2018, 10.25 pm

Introduction: What they say  A study from Nutritional Sciences and Toxicology Department, University of California, Berkeley, Berkeley, United States shows that “Dnmt3a is an epigenetic mediator […]