A sweet way to say no to metabolic disease: Sugar-based therapy for TIIDM and obesity-associated metabolic deficits: D-Mannose, a C-2 epimer of Glucose,, increases Lipocalin 2 (LCN2) expression, activates an MC4R-dependent anorexigenic pathway, suppresses appetite and weight gain, increases insulin secretion, improves glucose tolerance, promotes glucose homeostasis, improves obesity-associated metabolic deficits and prevents progression to TIIDM via down regulation of its target gene, 5/April/2018, 1.05 am