Ideas

August 29, 2018
Published by admin_auro at August 29, 2018
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Act(os) for an enhanced, extended, and healthy-lifespan: Pioglitazone (trade name: Actos), an anti-hyperglycemic agent, increases NMN/NAD levels, decreases interaction of DBC1 with PARP1, increases PARP1 activity, promotes DNA repair, augments tolerance against radiation, cancer, and aging, via down-regulation of its target gene, 29/August/2018, 8.09 am

Introduction: What they say A study from Department of Genetics, Paul F. Glenn Center for the Biology of Aging, Harvard Medical School, Boston, MA, USA; and […]
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August 29, 2018
Published by admin_auro at August 29, 2018
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Relaxin relieves you of stroke-risk: Relaxin, a protein hormone that facilitates labor and relaxes the uterine musculature, attenuates hippocampal neurons injury, augments regenerative neurogenesis after Ischemic Stroke, and ameliorates stroke damage and neurological deficits, via up-regulation of its target genes BDNF and NAMPT, 29/August/2018, 7.46 am

Introduction: What they say  A recent study from Research Center for Neurobiology and Department of Neurobiology, Xuzhou Medical College, 209 Tongshan Road, Xuzhou, Jiangsu 221004, PR China; […]
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August 27, 2018
Published by admin_auro at August 27, 2018
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Awakening the sleeping/cancer-protecting angels in mutant p53-expressing human tumors: PCGF2/Mel-18 increases the expression of tumor suppressors genes, such as  FBOX11, Sprouty1/2, p53, TAp63, TAp73, INK4a/ARF, and others, induces regression of p53-mutated human tumors, via down-regulation of its target gene, 28/August/2018, 12.17 am

From Significance of the study to Public health relevance:  Given that: (1) cancer suppressor p53 is mutated in more than 50% of human cancers of different […]
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August 27, 2018
Published by admin_auro at August 27, 2018
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Repurposing an anti-diabetic drug into an anti-cancer drug: Awakening the sleeping/cancer-protecting angels in mutant p53-expressing human tumors: Pioglitazone (trade name: Actos), an anti-diabetic drug, increases the expression of tumor suppressors genes, such as  TIMP3, CCM3/KRIT1, p53, TAp63, TAp73, INK4a/ARF, and others, induces regression of p53-mutated human tumors, via down-regulation of its target gene, 28/August/2018, 12.09 am

From Significance of the study to Public health relevance:  Given that: (1) cancer suppressor p53 is mutated in more than 50% of human cancers of different […]
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