Molecular therapy for Obesity-associated metabolic deficits/abnormalities: Mesencephalic astrocyte-derived neurotrophic factor (MANF) may aid in the treatment of TIIDM and obesity-associated metabolic deficits: MANF activates an MC4R-dependent anorexigenic pathway, suppresses appetite and weight gain, increases insulin secretion, improves glucose tolerance, promotes glucose homeostasis, improves obesity-associated metabolic deficits and prevents progression to TIIDM, via down-regulation of its target gene, 18/November/2018, 11.33 pm