Ideas

 Is music your way to keep the cardiac diseases at bay?: Music-based Regenerative therapy for regaining the lost cardiomyocytes in Myocardial patients:  Music  increases the expression of ERBB2/Her2 and promotes dedifferentiation  of cardiomyocytes via down-regulation of its target gene, 22/October/2018, 11.47 pm
 Is music your way to keep the cardiac diseases at bay?: Music-based Regenerative therapy for regaining the lost cardiomyocytes in Myocardial patients:  Music  increases the expression of ERBB2/Her2 and promotes dedifferentiation  of cardiomyocytes via down-regulation of its target gene, 22/October/2018, 11.47 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A recent study from the Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel shows that “ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation.” This study was published, in the 6 April…

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Repurposing the anti-hypertensive drug Diazoxide  into a diabetic retinopathy drug: A pharmaceutical mixture encompassing Diazoxide, Epicatechin and Matrine (DEM) inhibits Soluble epoxide hydrolase (sEH) expression, decreases toxic 19,20-dihydroxydocosapentaenoic acid levels, inhibits pericyte loss, vascular permeability, and inflammation of the eye and progression of diabetic retinopathy, via down-regulation of its target gene, 22/October/2018, 11.34 pm
Repurposing the anti-hypertensive drug Diazoxide  into a diabetic retinopathy drug: A pharmaceutical mixture encompassing Diazoxide, Epicatechin and Matrine (DEM) inhibits Soluble epoxide hydrolase (sEH) expression, decreases toxic 19,20-dihydroxydocosapentaenoic acid levels, inhibits pericyte loss, vascular permeability, and inflammation of the eye and progression of diabetic retinopathy, via down-regulation of its target gene, 22/October/2018, 11.34 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from the Institute for Vascular Signalling, Centre for Molecular Medicine, Goethe University, Frankfurt am Main, Germany; and German Centre for Cardiovascular Research (DZHK) partner…

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Cancer therapy targeting cancer stem cells in chronic myelogenous leukemia (CML) and other metastatic cancers: Misoprostol, an FDA-approved EP4 agonist and abortion-promoting drug, increases the expression of tumor suppressor genes, such as HNF4α, CADM1/2, p53, and TA-p73/p63, targets CML leukemic stem cells, confers protection against CML and prolongs survival, via up-regulation of its target gene, 22/October/2018,11.18 pm
Cancer therapy targeting cancer stem cells in chronic myelogenous leukemia (CML) and other metastatic cancers: Misoprostol, an FDA-approved EP4 agonist and abortion-promoting drug, increases the expression of tumor suppressor genes, such as HNF4α, CADM1/2, p53, and TA-p73/p63, targets CML leukemic stem cells, confers protection against CML and prolongs survival, via up-regulation of its target gene, 22/October/2018,11.18 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say: A study from the Department of Microbiology and Immunology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA shows that “Prostaglandin E1 and…

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Mechanistic insights into how anti-anxiety agent Lorazepam may deteriorate memory, learning, and cognition: Lorazepam (trade name: Ativan, Tavor, Temesta, and other), a medication used in the treatment of anxiety, seizures, sedation, agitation and others, decreases Tissue inhibitor of metalloproteinases 2 (TIMP2) and BDNF levels, attenuates cognition, and aggravates age-associated decline in memory and learning, via up-regulation of its target genes, 22/October/2018, 11.08 pm
Mechanistic insights into how anti-anxiety agent Lorazepam may deteriorate memory, learning, and cognition: Lorazepam (trade name: Ativan, Tavor, Temesta, and other), a medication used in the treatment of anxiety, seizures, sedation, agitation and others, decreases Tissue inhibitor of metalloproteinases 2 (TIMP2) and BDNF levels, attenuates cognition, and aggravates age-associated decline in memory and learning, via up-regulation of its target genes, 22/October/2018, 11.08 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California 94305, USA;  Paul F. Glenn Center for the Biology of…

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Act(os) against infective agents:  Pioglitazone (trade name: Actos), an anti-hyperglycemic drug, inhibits Hepatitis-B/C, Dengue, Zika, Ebola, HIV-1, Mtb, Malaria, CMV, Influenza H1NI1,  respiratory syncytial,  Sindbis, and SFV viruses by increasing the Levels of the antiviral Proteins IFITM3, & Interferon-stimulated gene 22/October/2018, 10.51 pm
Act(os) against infective agents:  Pioglitazone (trade name: Actos), an anti-hyperglycemic drug, inhibits Hepatitis-B/C, Dengue, Zika, Ebola, HIV-1, Mtb, Malaria, CMV, Influenza H1NI1,  respiratory syncytial,  Sindbis, and SFV viruses by increasing the Levels of the antiviral Proteins IFITM3, & Interferon-stimulated gene 22/October/2018, 10.51 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say: A study from the Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard Medical School, Charlestown, MA 02129, USA shows that “The IFITM proteins…

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Stalling arthritic pain with probiotics: Probiotic Lactobacillus acidophilus increases IL-9 levels, augments proliferation of ILC2s (type 2 innate lymphoid cells) and regulatory T (Treg) cells, promotes resolution of inflammation, attenuates cartilage destruction, decreases bone loss, and inhibits pathological features associated with arthritis via up-regulation of its target genes, 22/October/2018, 10.35 pm
Stalling arthritic pain with probiotics: Probiotic Lactobacillus acidophilus increases IL-9 levels, augments proliferation of ILC2s (type 2 innate lymphoid cells) and regulatory T (Treg) cells, promotes resolution of inflammation, attenuates cartilage destruction, decreases bone loss, and inhibits pathological features associated with arthritis via up-regulation of its target genes, 22/October/2018, 10.35 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from Department of Internal Medicine 3-Rheumatology and Immunology, Friedrich Alexander University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Germany shows that “Resolution of inflammation by…

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