Ideas

A musical way to stay free of diabetes: Music-based therapy for body weight control, energy homeostasis, and TIIDM: Music inhibits DNA methyltransferase 3a (Dnmt3a) expression, increases FGF21 expression, augments insulin sensitivity, increases glucose tolerance, and protects from diet-induced obesity and TIIDM, via up-regulation of its target gene, 22/September/2018, 10.25 pm
A musical way to stay free of diabetes: Music-based therapy for body weight control, energy homeostasis, and TIIDM: Music inhibits DNA methyltransferase 3a (Dnmt3a) expression, increases FGF21 expression, augments insulin sensitivity, increases glucose tolerance, and protects from diet-induced obesity and TIIDM, via up-regulation of its target gene, 22/September/2018, 10.25 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say  A study from Nutritional Sciences and Toxicology Department, University of California, Berkeley, Berkeley, United States shows that “Dnmt3a is an epigenetic mediator of adipose insulin resistance.”…

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Taming cancers with anti-tapeworm drugs: Niclosamide (brand name: Niclocide, Fenasal, Phenasal), an anti-tapeworm drug,  increases the expression of tumor suppressors genes, such as TIMP3, PDCD4, p53, TAp63, TAp73, INK4a/ARF, and others, and induces regression of p53-mutated human cancers and other cancers, via up-regulation of its target gene, 22/October/2018, 10.13  pm
Taming cancers with anti-tapeworm drugs: Niclosamide (brand name: Niclocide, Fenasal, Phenasal), an anti-tapeworm drug,  increases the expression of tumor suppressors genes, such as TIMP3, PDCD4, p53, TAp63, TAp73, INK4a/ARF, and others, and induces regression of p53-mutated human cancers and other cancers, via up-regulation of its target gene, 22/October/2018, 10.13  pm 960 720 Dr Boomi's Genom-2-Discovery Center

From Significance of the study to Public health relevance:  Given that: (1) cancer suppressor p53 is mutated in more than 50% of human cancers of different tissue origin; (2) p53…

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Mechanistic insights into how Diazoxide functions as a learning/memory/cognitive-enhancer: Diazoxide (brand name: Proglycem), a vasodilator used in the treatment of hypertension, insulinoma etc.,, increases Tissue inhibitor of metalloproteinases 2 (TIMP2) levels, improves cognition, and decreases age-associated decline in memory and learning, via down regulation of its target genes, 22/October/2018, 10.02 pm
Mechanistic insights into how Diazoxide functions as a learning/memory/cognitive-enhancer: Diazoxide (brand name: Proglycem), a vasodilator used in the treatment of hypertension, insulinoma etc.,, increases Tissue inhibitor of metalloproteinases 2 (TIMP2) levels, improves cognition, and decreases age-associated decline in memory and learning, via down regulation of its target genes, 22/October/2018, 10.02 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say: A study from Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California 94305, USA;  Paul F. Glenn Center for the Biology of…

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Stalling arthritic pain with probiotics: Probiotic Bacillus clousii increases IL-9 levels, augments proliferation of ILC2s (type 2 innate lymphoid cells) and regulatory T (Treg) cells, promotes resolution of inflammation, attenuates cartilage destruction, decreases bone loss, and inhibits pathological features associated with arthritis via up-regulation of its target genes, 21/October/2018, 1o.33 pm
Stalling arthritic pain with probiotics: Probiotic Bacillus clousii increases IL-9 levels, augments proliferation of ILC2s (type 2 innate lymphoid cells) and regulatory T (Treg) cells, promotes resolution of inflammation, attenuates cartilage destruction, decreases bone loss, and inhibits pathological features associated with arthritis via up-regulation of its target genes, 21/October/2018, 1o.33 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from Department of Internal Medicine 3-Rheumatology and Immunology, Friedrich Alexander University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Germany shows that “Resolution of inflammation by…

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The tiny probiotic Lactobacillus sakei K17 may function as a Pain medication:  Probiotic Lactobacillus sakei K17 increases the expression of PD-L1, attenuates acute and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability, via up-regulation of its target gene, 21/October/2018, 10.17 pm
The tiny probiotic Lactobacillus sakei K17 may function as a Pain medication:  Probiotic Lactobacillus sakei K17 increases the expression of PD-L1, attenuates acute and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability, via up-regulation of its target gene, 21/October/2018, 10.17 pm 960 720 Dr Boomi's Genom-2-Discovery Center

 Introduction: What they say: A recent study from Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for Brain Science, Fudan University,…

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A probiotic way to insulate your heart against cardiac dysfunction: Probiotic Lactobacillus sakei-based adjuvant therapy for cardiac hypertrophy and fibrosis: Probiotic Lactobacillus sakei OK67 decreases Mir-29 expression, activates Wnt- signaling and its components GSK3B, ICAT/CTNNBIP1, HBP1, and GLIS2, attenuates pathologic hypertrophy, inhibits fibrosis of the heart tissue, and improves cardiac function via upregulation of its target gene, 20/October/2018, 5.35 pm
A probiotic way to insulate your heart against cardiac dysfunction: Probiotic Lactobacillus sakei-based adjuvant therapy for cardiac hypertrophy and fibrosis: Probiotic Lactobacillus sakei OK67 decreases Mir-29 expression, activates Wnt- signaling and its components GSK3B, ICAT/CTNNBIP1, HBP1, and GLIS2, attenuates pathologic hypertrophy, inhibits fibrosis of the heart tissue, and improves cardiac function via upregulation of its target gene, 20/October/2018, 5.35 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say:   A recent study from the Institute of Pharmacology and Toxicology, Technical University Munich (TUM), 80802, Munich, Germany; DZHK (German Center for Cardiovascular Research), partner site Munich…

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