Ideas

Mechanistic insights into how  Tofacitinib attenuates rheumatoid arthritis:  Tofacitinib (brand name: Xeljanz), used to treat  rheumatoid/psoriatic arthritis and ulcerative colitis, increases IL-9 levels, augments proliferation of ILC2s (type 2 innate lymphoid cells) and regulatory T (Treg) cells, promotes resolution of inflammation, attenuates cartilage destruction, decreases bone loss, and inhibits pathological features associated with arthritis via up-regulation of its target genes, 5/August/2018, 1.29 am
Mechanistic insights into how  Tofacitinib attenuates rheumatoid arthritis:  Tofacitinib (brand name: Xeljanz), used to treat  rheumatoid/psoriatic arthritis and ulcerative colitis, increases IL-9 levels, augments proliferation of ILC2s (type 2 innate lymphoid cells) and regulatory T (Treg) cells, promotes resolution of inflammation, attenuates cartilage destruction, decreases bone loss, and inhibits pathological features associated with arthritis via up-regulation of its target genes, 5/August/2018, 1.29 am 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from Department of Internal Medicine 3-Rheumatology and Immunology, Friedrich Alexander University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Germany shows that “Resolution of inflammation by…

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Probiotic-based chemotherapy targeting cancer stem cells and immune-inhibitory receptors in advanced ovarian cancer and other metastatic cancers: A pharmaceutical mixture encompassing Olaparib, an FDA-approved poly (adenosine diphosphate-ribose) polymerase inhibitor, and probiotic Lactobacillus rhamnosus increases the expression of tumor suppressor genes, such as FASLG, KLF5,  p53, and TA-p73/p63, inhibits immune-inhibitory receptors/molecules, targets ovarian cancer stem cells, confers protection against chemoresistance and prolongs survival, via up-regulation of its target gene, 4/August/2019, 1.11 am
Probiotic-based chemotherapy targeting cancer stem cells and immune-inhibitory receptors in advanced ovarian cancer and other metastatic cancers: A pharmaceutical mixture encompassing Olaparib, an FDA-approved poly (adenosine diphosphate-ribose) polymerase inhibitor, and probiotic Lactobacillus rhamnosus increases the expression of tumor suppressor genes, such as FASLG, KLF5,  p53, and TA-p73/p63, inhibits immune-inhibitory receptors/molecules, targets ovarian cancer stem cells, confers protection against chemoresistance and prolongs survival, via up-regulation of its target gene, 4/August/2019, 1.11 am 1280 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say: A study from the Stephenson Cancer Center at the University of Oklahoma, Oklahoma City (K.M.), USA; University of Milan-Bicocca, European Institute of Oncology Istituto di Ricovero…

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Probiotic-based chemotherapy targeting cancer stem cells and immune-inhibitory receptors in chronic lymphocytic leukemia (CLL) and in advanced metastatic cancers: A pharmaceutical mixture encompassing Venetoclax and Ibrutinib (VAI) and probiotic Lactobacillus rhamnosus increases the expression of tumor suppressor genes, such as LZTFL1 (Leucine Zipper Transcription Factor Like 1), ACAT1 (Acetyl-CoA Acetyltransferase 1), p53, and TA-p73/p63, inhibits immune-inhibitory receptors/molecules, targets cancer stem cells, confers protection against chemoresistance and prolongs survival, and stalls CLL progression, via up-regulation of its target gene, 02/August/2019, 11.13 pm
Probiotic-based chemotherapy targeting cancer stem cells and immune-inhibitory receptors in chronic lymphocytic leukemia (CLL) and in advanced metastatic cancers: A pharmaceutical mixture encompassing Venetoclax and Ibrutinib (VAI) and probiotic Lactobacillus rhamnosus increases the expression of tumor suppressor genes, such as LZTFL1 (Leucine Zipper Transcription Factor Like 1), ACAT1 (Acetyl-CoA Acetyltransferase 1), p53, and TA-p73/p63, inhibits immune-inhibitory receptors/molecules, targets cancer stem cells, confers protection against chemoresistance and prolongs survival, and stalls CLL progression, via up-regulation of its target gene, 02/August/2019, 11.13 pm 1280 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from the University of Texas M.D. Anderson Cancer Center, Houston, USA shows that “Ibrutinib and Venetoclax for First-Line Treatment of CLL.” This research paper was published, in…

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Live longer by consuming polyamine-rich foods: Spermine-based Lifespan extension therapy:  Spermine, one of the polyamines,  inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian lifespan by regulating the expression of its target genes, 1/August/2019, 11.29 pm
Live longer by consuming polyamine-rich foods: Spermine-based Lifespan extension therapy:  Spermine, one of the polyamines,  inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian lifespan by regulating the expression of its target genes, 1/August/2019, 11.29 pm 1280 720 Dr Boomi's Genom-2-Discovery Center

What they say: A study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase 1…

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Solving a fifty plus year puzzle as to how labor pain relief medication Fentanyl functions as a pain reliever: Mechanistic insights into how Fentanyl  functions as an analgesic agent: Fentanyl (trade name: Actiq, Duragesic, Fentora, Sublimaze and others), used to treat moderate to severe pain during labor and delivery, in post-operative pain management, in chronic cancer pain management and in others,  increases the expression of PD-L1, decreases the expression of Cox-2, TRPV1, and CGPR, attenuates acutes and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability, via up-regulation of its target gene, 31/July/2019, 8.09 pm
Solving a fifty plus year puzzle as to how labor pain relief medication Fentanyl functions as a pain reliever: Mechanistic insights into how Fentanyl  functions as an analgesic agent: Fentanyl (trade name: Actiq, Duragesic, Fentora, Sublimaze and others), used to treat moderate to severe pain during labor and delivery, in post-operative pain management, in chronic cancer pain management and in others,  increases the expression of PD-L1, decreases the expression of Cox-2, TRPV1, and CGPR, attenuates acutes and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability, via up-regulation of its target gene, 31/July/2019, 8.09 pm 1280 720 Dr Boomi's Genom-2-Discovery Center

Introduction:What they say: A recent study from Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for Brain Science, Fudan University, Shanghai,…

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Probiotics as biological drugs: Repurposing the Probiotic Verrucomicrobia Akkermansia Muciniphila into a longevity/healthspan-promoting bio-drug:  Probiotic Verrucomicrobia Akkermansia Muciniphila inhibits the interaction of DBC1 with PARP1, increases the PARP1 activity, promotes DNA repair, augments tolerance against radiation, cancer, and aging, via down-regulation of its target gene, 30/July/2019, 8.39 am
Probiotics as biological drugs: Repurposing the Probiotic Verrucomicrobia Akkermansia Muciniphila into a longevity/healthspan-promoting bio-drug:  Probiotic Verrucomicrobia Akkermansia Muciniphila inhibits the interaction of DBC1 with PARP1, increases the PARP1 activity, promotes DNA repair, augments tolerance against radiation, cancer, and aging, via down-regulation of its target gene, 30/July/2019, 8.39 am 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from Department of Genetics, Paul F. Glenn Center for the Biology of Aging, Harvard Medical School, Boston, MA, USA; and Department of Pharmacology, School…

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