Ideas

May 7, 2019

Mechanistic insights into how analgesic agent Cannabidiol (CBD) attenuates pain: Cannabidiol (CBD), an analgesic drug derived from hemp and others, increases the expression of PD-L1, attenuates acute and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability via up-regulation of its target gene, 7/May/2019, 6.04 am

Introduction:What they say: A recent study from Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for Brain […]
May 5, 2019

Yes to Autophagy, no to Diabetes: Mechanistic insights into how autophagy may ameliorate Diabetes Mellitus: Acute or intermittent autophagy  augments the expression of FGF19 and FGF1,  attenuates hepatic glucose production, decreases hepatic acetyl CoA content, brings down the levels of plasma ACTH, and corticosterone, augments insulin sensitivity, promotes weight loss and alleviates TIDM, via upregulation of its target gene, 5/May/2019, 7.37 am

Introduction: What they say  A study from Diabetes and Obesity Center of Excellence, Department of Medicine, University of Washington, Seattle, Washington, USA shows that Central injection […]
May 5, 2019

Mechanistic insights into how Liraglutide may aid in the treatment of Diabetes: Liraglutide (brand name: Victoza, Saxenda, others), an acylated glucagon-like peptide-1 (GLP-1) agonist used in the treatment of Type II diabetes, increases GLP1R and Caveolin-1 (CAV-1) expression, promotes glucose-induced insulin secretion, improves insulin sensitivity, increases energy utilization, promotes weight loss and protects from diet-induced obesity and TIIDM, via up-regulation of its target gene, 5/May/2018, 7.09 am

Introduction: What they say A study from the Comprehensive Diabetes Center and Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, the University of Alabama at […]
May 5, 2019

Mechanistic insights into how Canagliflozin aids in control of body weight, energy homeostasis and TIIDM:  Canagliflozin (brand name: Invokana, Sulisent, Prominad, others), a  drug used in the treatment of type II diabetes, increases REV-ERB and its down stream target genes, inhibits lipid accumulation, improves dyslipidemia and insulin sensitivity, increases energy utilization, promotes weight loss and protects from diet-induced obesity and TIIDM, via up regulation of its target gene, 5/May/2019, 6.39 am

Introduction: What they say A study from the Department of Molecular Therapeutics, The Scripps Research Institute, Jupiter, Florida 33458, USA shows that “Regulation of circadian behaviour […]
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