Ideas

Solving a seventy plus year puzzle as to how labor pain relief medication Pethidine functions as a pain reliever: Mechanistic insights into how Pethidine  functions as an analgesic agent: Pethidine (trade name: Meperidine/Demerol), used to decrease feeling in a specific area of the body, in post-operative pain management, in the treatment of lower back pain and in others,  increases the expression of PD-L1, decreases the expression of Cox-2, TRPV1, and CGPR, attenuates acutes and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability, via up-regulation of its target gene, 29/July/2019, 2.48 pm
Solving a seventy plus year puzzle as to how labor pain relief medication Pethidine functions as a pain reliever: Mechanistic insights into how Pethidine  functions as an analgesic agent: Pethidine (trade name: Meperidine/Demerol), used to decrease feeling in a specific area of the body, in post-operative pain management, in the treatment of lower back pain and in others,  increases the expression of PD-L1, decreases the expression of Cox-2, TRPV1, and CGPR, attenuates acutes and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability, via up-regulation of its target gene, 29/July/2019, 2.48 pm 1280 720 Dr Boomi's Genom-2-Discovery Center

Introduction:What they say: A recent study from Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for Brain Science, Fudan University, Shanghai,…

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Solving a sixty plus year puzzle as to how Bupivacaine functions as a pain reliever: Mechanistic insights into how Bupivacaine functions as a local anesthetic agent: Bupivacaine  (trade name: Marcaine, Sensorcaine, Vivacaine, others ), used to decrease feeling in a specific area of the body, in post-operative pain management, in the treatment of lower back pain and in others,  increases the expression of PD-L1, decreases the expression of Cox-2, TRPV1, and CGPR, attenuates acutes and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability, via up-regulation of its target gene, 24/July/2019, 6.34 am
Solving a sixty plus year puzzle as to how Bupivacaine functions as a pain reliever: Mechanistic insights into how Bupivacaine functions as a local anesthetic agent: Bupivacaine  (trade name: Marcaine, Sensorcaine, Vivacaine, others ), used to decrease feeling in a specific area of the body, in post-operative pain management, in the treatment of lower back pain and in others,  increases the expression of PD-L1, decreases the expression of Cox-2, TRPV1, and CGPR, attenuates acutes and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability, via up-regulation of its target gene, 24/July/2019, 6.34 am 1280 720 Dr Boomi's Genom-2-Discovery Center

Introduction:What they say: A recent study from Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for Brain Science, Fudan University, Shanghai,…

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Probiotic-based therapy for aging-associated diseases and Lifespan extension: A therapeutic mix encompassing Probiotic Bifidobacterium LKM512 and Arginine inhibits the interaction of DBC1 with PARP1, increases the PARP1 activity, promotes DNA repair, augments tolerance against radiation, cancer, and aging, via down-regulation of its target gene, 23/July/2019, 8.03 am
Probiotic-based therapy for aging-associated diseases and Lifespan extension: A therapeutic mix encompassing Probiotic Bifidobacterium LKM512 and Arginine inhibits the interaction of DBC1 with PARP1, increases the PARP1 activity, promotes DNA repair, augments tolerance against radiation, cancer, and aging, via down-regulation of its target gene, 23/July/2019, 8.03 am 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from Department of Genetics, Paul F. Glenn Center for the Biology of Aging, Harvard Medical School, Boston, MA, USA; and Department of Pharmacology, School…

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Solving a sixty-year old puzzle as to how Amitriptyline functions as a pain reliever: Mechanistic insights into how Amitriptyline functions as a pain medication: Amitriptyline (trade name: Elatrol, Elatrolet, Elavil, Endep, Fiorda, Laroxyl, Latilin, Levate and others), used in the treatment for major depressive order, and anxiety disorders, prevention of migraines, fibromyalgia, postherpetic neuralgia, and insomnia,  increases the expression of PD-L1, decreases the expression of Cox-2, TRPV1, and CGPR, attenuates acutes and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability, via up-regulation of its target gene, 12/July/2019, 11.29 pm
Solving a sixty-year old puzzle as to how Amitriptyline functions as a pain reliever: Mechanistic insights into how Amitriptyline functions as a pain medication: Amitriptyline (trade name: Elatrol, Elatrolet, Elavil, Endep, Fiorda, Laroxyl, Latilin, Levate and others), used in the treatment for major depressive order, and anxiety disorders, prevention of migraines, fibromyalgia, postherpetic neuralgia, and insomnia,  increases the expression of PD-L1, decreases the expression of Cox-2, TRPV1, and CGPR, attenuates acutes and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability, via up-regulation of its target gene, 12/July/2019, 11.29 pm 1280 720 Dr Boomi's Genom-2-Discovery Center

Introduction:What they say: A recent study from Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for Brain Science, Fudan University, Shanghai,…

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Thymol-based regenerative therapy for improving cognitive deficits in the aged individuals: Thymol, isolated from Trachyspermum Ammi/Ajwain seeds and oil,  decreases vascular cell adhesion molecule 1 (VCAM 1), inhibits microglia activity, increases hippocampal neural precursor activity, ameliorates cognition, & attenuates age-related neurodegeneration, through up regulation of its target genes, 19/July/2019, 9.29 pm
Thymol-based regenerative therapy for improving cognitive deficits in the aged individuals: Thymol, isolated from Trachyspermum Ammi/Ajwain seeds and oil,  decreases vascular cell adhesion molecule 1 (VCAM 1), inhibits microglia activity, increases hippocampal neural precursor activity, ameliorates cognition, & attenuates age-related neurodegeneration, through up regulation of its target genes, 19/July/2019, 9.29 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from the Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA, VA Palo Alto Health Care System, Palo Alto,…

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Natural product-derived Analgesics:  Mechanistic insights into how natural product-derived Manassantin B  functions as a pain medication: Manassantin B, isolated from Saururus chinensis (also known as Asian lizard’s tail), increases the expression of PD-L1, TRPV1, and CGPR, decreases the expression of Cox-2, attenuates acutes and chronic pain, headache, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability, via up-regulation of its target gene, 17/July/2019, 10.23 am
Natural product-derived Analgesics:  Mechanistic insights into how natural product-derived Manassantin B  functions as a pain medication: Manassantin B, isolated from Saururus chinensis (also known as Asian lizard’s tail), increases the expression of PD-L1, TRPV1, and CGPR, decreases the expression of Cox-2, attenuates acutes and chronic pain, headache, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability, via up-regulation of its target gene, 17/July/2019, 10.23 am 1280 720 Dr Boomi's Genom-2-Discovery Center

Introduction:What they say: A recent study from Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for Brain Science, Fudan University, Shanghai,…

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