Ideas

A sweet way to say no to weight gain and Diabetes: Sugar-based therapy for body weight control, energy homeostasis and TIIDM: D-Mannose, a C-2 epimer of glucose, decreases CADM1 and its downstream target genes that inhibit glucose-induced insulin secretion, improves insulin sensitivity, increases energy utilization, promotes weight loss and protects from diet-induced obesity and TIIDM, via up regulation of its target gene, 18/March/2017, 9.53 am
A sweet way to say no to weight gain and Diabetes: Sugar-based therapy for body weight control, energy homeostasis and TIIDM: D-Mannose, a C-2 epimer of glucose, decreases CADM1 and its downstream target genes that inhibit glucose-induced insulin secretion, improves insulin sensitivity, increases energy utilization, promotes weight loss and protects from diet-induced obesity and TIIDM, via up regulation of its target gene, 18/March/2017, 9.53 am 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from the Max Delbrück Center for Molecular Medicine, Berlin, Germany shows that “Regulation of body weight and energy homeostasis by neuronal cell adhesion molecule1.”…

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A candy way to say no to pain: Rare sugar-based therapy for inflammation and arthritis:D-Allose, an aldohexose sugar and C-3 epimer of glucose, increases IL-9 levels, augments proliferation of ILC2s (type 2 innate lymphoid cells) and regulatory T (Treg) cells, promotes resolution of inflammation, attenuates cartilage destruction, decreases bone loss, and inhibits pathological features associated with arthritis via up-regulation of its target genes, 18/March/2018, 9.34 am
A candy way to say no to pain: Rare sugar-based therapy for inflammation and arthritis:D-Allose, an aldohexose sugar and C-3 epimer of glucose, increases IL-9 levels, augments proliferation of ILC2s (type 2 innate lymphoid cells) and regulatory T (Treg) cells, promotes resolution of inflammation, attenuates cartilage destruction, decreases bone loss, and inhibits pathological features associated with arthritis via up-regulation of its target genes, 18/March/2018, 9.34 am 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from Department of Internal Medicine 3-Rheumatology and Immunology, Friedrich Alexander University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Germany shows that “Resolution of inflammation by…

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A candy way to extend lifespan: Sugar-based Lifespan extension therapy: Erythritol, a sugar alcohol/non-caloric sugar/food additive, may increase life span, via up-regulation of its target gene BubR1, 18/March/2018, 9.14 am
A candy way to extend lifespan: Sugar-based Lifespan extension therapy: Erythritol, a sugar alcohol/non-caloric sugar/food additive, may increase life span, via up-regulation of its target gene BubR1, 18/March/2018, 9.14 am 960 720 Dr Boomi's Genom-2-Discovery Center

 What they say: Introduction:  A recent study from the Department of Genetics, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Harvard Medical School, Boston,USA; and Department of Pharmacology, School…

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A candy way to treat Non-alcoholic fatty liver disease: Sugar-based therapy for Non-alcoholic fatty liver disease (NAFLD): D-Mannose, a C-2 epimer of glucose, promotes degradation of HMGCR, decreases the levels of triglycerides, free cholesterol, and total cholesterol and prevents the progression of Non-alcoholic fatty liver disease (NAFLD via down regulation of its target gene, 18/March/2018, 8.51 am
A candy way to treat Non-alcoholic fatty liver disease: Sugar-based therapy for Non-alcoholic fatty liver disease (NAFLD): D-Mannose, a C-2 epimer of glucose, promotes degradation of HMGCR, decreases the levels of triglycerides, free cholesterol, and total cholesterol and prevents the progression of Non-alcoholic fatty liver disease (NAFLD via down regulation of its target gene, 18/March/2018, 8.51 am 960 720 Dr Boomi's Genom-2-Discovery Center

Significance of the study: Given that: (1)  15-30% of Western populations suffer from Non-alcoholic fatty liver disease (NAFLD), while 6-25% of Asian populations suffer from it; (2) 75 to 100 million people in…

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Rare Sugar-based therapy for Metastatic cancers: Xylobiose, a disaccharide of xylose, increases the expression of tumor/metastatic suppressors PTEN and PDCD4, inhibits cell cycle progression, and suppresses migration, invasion and metastasis of cancer cells via up regulation of its target gene, 18/March/2018, 8.35 am
Rare Sugar-based therapy for Metastatic cancers: Xylobiose, a disaccharide of xylose, increases the expression of tumor/metastatic suppressors PTEN and PDCD4, inhibits cell cycle progression, and suppresses migration, invasion and metastasis of cancer cells via up regulation of its target gene, 18/March/2018, 8.35 am 960 720 Dr Boomi's Genom-2-Discovery Center

From Significance of the study to Public health relevance:  Given that: (i) each year nearly 14 million people are diagnosed with cancer globally, and little more than half of them…

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A candy way to extend lifespan: Sugar-based Lifespan extension therapy: Xylitol, a sugar alcohol and artificial sweetener in drugs, confections, toothpaste, and chewing gum, may increase life span, via up-regulation of its target gene BubR1, 17/March/2018, 9.01 am
A candy way to extend lifespan: Sugar-based Lifespan extension therapy: Xylitol, a sugar alcohol and artificial sweetener in drugs, confections, toothpaste, and chewing gum, may increase life span, via up-regulation of its target gene BubR1, 17/March/2018, 9.01 am 960 720 Dr Boomi's Genom-2-Discovery Center

 What they say: Introduction:  A recent study from the Department of Genetics, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Harvard Medical School, Boston,USA; and Department of Pharmacology, School…

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