Ideas

Polyamine-based Lifespan extension therapy: Spermidine prolongs mammalian life span via down regulation of angiotensin II type I receptor (AT1R), 4/March/2018, 12.17 pm
Polyamine-based Lifespan extension therapy: Spermidine prolongs mammalian life span via down regulation of angiotensin II type I receptor (AT1R), 4/March/2018, 12.17 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Significance of the study: It has been shown earlier that antagonizing angiotensin II type I receptor (AT1R) expression may prolong mammalian life span. Further, it has been shown that disruption of AT1R (AGTR1)…

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Amino acid-based therapy for TIIDM and obesity-associated metabolic deficits: Glycine, a non-essential amino acid and inhibitory neurotransmitter,  increases Lipocalin 2 (LCN2) expression, activates an MC4R-dependent anorexigenic pathway, suppresses appetite and weight gain, increases insulin secretion, improves glucose tolerance, promotes glucose homeostasis, improves obesity-associated metabolic deficits and prevents progression to TIIDM via down regulation of its target gene, 4/March/2018, 11.45 am
Amino acid-based therapy for TIIDM and obesity-associated metabolic deficits: Glycine, a non-essential amino acid and inhibitory neurotransmitter,  increases Lipocalin 2 (LCN2) expression, activates an MC4R-dependent anorexigenic pathway, suppresses appetite and weight gain, increases insulin secretion, improves glucose tolerance, promotes glucose homeostasis, improves obesity-associated metabolic deficits and prevents progression to TIIDM via down regulation of its target gene, 4/March/2018, 11.45 am 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from the Department of Physiology-Cellular Biophysics, College of Physicians and Surgeons, Columbia University, New York, New York, USA shows that “MC4R-dependent suppression of appetite by…

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 Non-absorbable sugar based Lifespan extension therapy:  Lactulose (brand names: Cholac, Generlac, Consulose, Duphalac, others), a non-absorbable sugar aids in the treatment of constipation and hepatic encephalopathy,  increases life span via up-regulation of its target gene BubR1, 4/March/2018, 11.27 am
 Non-absorbable sugar based Lifespan extension therapy:  Lactulose (brand names: Cholac, Generlac, Consulose, Duphalac, others), a non-absorbable sugar aids in the treatment of constipation and hepatic encephalopathy,  increases life span via up-regulation of its target gene BubR1, 4/March/2018, 11.27 am 960 720 Dr Boomi's Genom-2-Discovery Center

 What they say: Introduction:  A recent study from the Department of Genetics, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Harvard Medical School, Boston,USA; and Department of Pharmacology, School…

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Activation of the PD-1 pathway for Pain therapy: DAMGO ([D-Ala2, N-MePhe4, Gly-ol]-enkephalin), a synthetic opioid peptide, increases the expression of PD-L1, attenuates acutes and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability via up-regulation of its target gene, 4/March/2017, 11.07 am
Activation of the PD-1 pathway for Pain therapy: DAMGO ([D-Ala2, N-MePhe4, Gly-ol]-enkephalin), a synthetic opioid peptide, increases the expression of PD-L1, attenuates acutes and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability via up-regulation of its target gene, 4/March/2017, 11.07 am 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction:What they say: A recent study, from Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for Brain Science, Fudan University, Shanghai,…

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 A glass of milk a day keeps the cardiac diseases at bay: Regenerative therapy for regaining the lost cardiomyocytes in Myocardial patients:  Human or Cow’s milk increases the expression of ERBB2/Her2 and promotes dedifferentiation  of cardiomyocytes via down regulation of its target gene, 3/March/2018, 9.40 am
 A glass of milk a day keeps the cardiac diseases at bay: Regenerative therapy for regaining the lost cardiomyocytes in Myocardial patients:  Human or Cow’s milk increases the expression of ERBB2/Her2 and promotes dedifferentiation  of cardiomyocytes via down regulation of its target gene, 3/March/2018, 9.40 am 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A recent study from the Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel shows that “ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation.” This study was published, in the 6 April…

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Molecular therapy for tuberculosis: Carvedilol (brand name: Coreg), used in treatment of congestive heart failure and left ventricular dysfunction, deacetylates RelA/p65, inhibits inflammatory gene expression downstream of RelA/p65, inhibits TB pathogenesis, increases the efficacy of anti-TB drug, and promotes M. tuberculosis clearance via up regulation of its target gene, 3/March/2018, 9.23 am
Molecular therapy for tuberculosis: Carvedilol (brand name: Coreg), used in treatment of congestive heart failure and left ventricular dysfunction, deacetylates RelA/p65, inhibits inflammatory gene expression downstream of RelA/p65, inhibits TB pathogenesis, increases the efficacy of anti-TB drug, and promotes M. tuberculosis clearance via up regulation of its target gene, 3/March/2018, 9.23 am 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say: A study from the Singapore Immunology Network, Agency for Science, Technology and Research, Singapore; and Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore shows…

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