Ideas

August 1, 2018
Published by admin_auro at August 1, 2018
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Repurposing the H.Pylori vaccine CTB-UE into an anti-diabetic vaccine:  CTB-UE vaccine-based therapy for body weight control, energy homeostasis and TIIDM:CTB-UE vaccine, protects against infections caused by H.Pylori, inhibits DNA methyltransferase 3a (Dnmt3a) expression, increases FGF21 expression, augments insulin sensitivity, increases glucose tolerance, and protects from diet-induced obesity and TIIDM, via up-regulation of its target gene, 1/August/2018, 3.34 pm

Introduction: What they say  A study from Nutritional Sciences and Toxicology Department, University of California, Berkeley, Berkeley, United States shows that “Dnmt3a is an epigenetic mediator […]
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August 1, 2018
Published by admin_auro at August 1, 2018
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Awakening the sleeping/cancer-protecting angels in mutant p53-expressing human tumors: Emodin, isolated from Rhubarb and others,  increases the expression of tumor suppressors genes, such as  BigH3, TIPE2, TA-p73, TAp63, p53, and others, induces regression of p53-mutated human tumors, via down-regulation of its target gene, 1/August/2018, 3.21 pm

From Significance of the study to Public health relevance:  Given that: (1) cancer suppressor p53 is mutated in more than 50% of human cancers of different […]
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August 1, 2018
Published by admin_auro at August 1, 2018
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Vaccine for lowering cholesterol, and triglycerides levels: Repurposing the CTB-UE vaccine into a cholesterol-lowering vaccine that inhibits Non-alcoholic fatty liver disease (NAFLD): CTB-UE vaccine, which protects against H.Pylori infection, decreases the levels of HMGCR,  triglycerides, free cholesterol, and total cholesterol and prevents the progression of Non-alcoholic fatty liver disease (NAFLD, via down regulation of its target gene, 1/August/2018, 3.16 pm

Significance of the study: Given that: (1)  15-30% of Western populations suffer from Non-alcoholic fatty liver disease (NAFLD), while 6-25% of Asian populations suffer from it; (2) 75 to […]
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August 1, 2018
Published by admin_auro at August 1, 2018
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Bacillus Calmette Guerin (BCG)/tuberculosis (TB) vaccine aids in the treatment of Deafness: BCG/TB vaccine increases the expression of ATG5 (Autophagy-related 5), prevents aggregation of proteins in inclusion bodies, inhibits hair cell degeneration,  improves hearing loss via upregulation of its target genes, 1/August/2018, 2.10 pm

  What we say: Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that:  Bacillus Calmette Guerin (BCG)/tuberculosis (TB) aids in the treatment of Deafness: BCG/TB vaccine increases the expression […]
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