Ideas

April 21, 2018

Published by admin_auro at April 21, 2018

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Turning on the sleeping/cancer-protecting angels in mutant p53-expressing human tumors: Valsartan, a medication used in the treatment of high blood pressure and congestive heart failure, increases the expression of tumor suppressors genes, such as GRHL3, long ncRNA Gas5, BigH3, TIPE2, PTEN, PDCD4, INK4a, BTG2, TA-p73/p63, TPM1, TIMP3, CCM1/KRIT1 and others, induces regression of p53-mutated human tumors, via down regulation of its target gene, 21/April/2017, 8.00 am

From Significance of the study to Public health relevance: Given that: (1) cancer suppressor p53 is mutated in more than 50% of human cancers of different […]

April 21, 2018

Published by admin_auro at April 21, 2018

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Natural product-derived therapy for Malaria: Nordihydroguaiaretic acid (NDGA) increases Ferroportin expression, decreases intracellular iron accumulation, inhibits cellular damage, prevents hemolysis, and inhibits malaria infection, via upregulation of its target gene, 21/April/2018, 7.40 am

Introduction: What they say: A study from the Section on Human Iron Metabolism, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes […]

April 21, 2018

Published by admin_auro at April 21, 2018

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A sweet way to protect your heart from cardiac diseases and cardiac ageing: Phyllodulcin, a natural sweetener 400-800 times sweeter than sugar, inhibits DNA damage responses, induces telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction, via up regulation of PNUTS, 21/April/2018, 7.33 am

What they say: A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published, in the 7 March 2013 issue of of […]

April 21, 2018

Published by admin_auro at April 21, 2018

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Ideas
Pain

Bonding your way to lead a pain-free life: Oxytocin-based activation of the PD-1 pathway for Pain therapy: Oxytocin (also known as compassion/goodness/bonding hormone), a peptide hormone and neuropeptide known to play a role in empathy, generosity, childbirth and so on, increases the expression of PD-L1, attenuates acutes and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability via up-regulation of its target gene, 21/April/2018, 7.07 am

Introduction:What they say: A recent study, from Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for Brain […]