Ideas

Natural product therapy for Glaucoma: Formononetin, isolated from Trifolium Pratense, Maackia Amurensis/Amur Maackia, among others, increases Nmnat1 expression, increases NAD+ levels, improves neuronal dysfunction, and protects against glaucoma via down regulation of its target gene, 27/November/2017, 8.07 am
Natural product therapy for Glaucoma: Formononetin, isolated from Trifolium Pratense, Maackia Amurensis/Amur Maackia, among others, increases Nmnat1 expression, increases NAD+ levels, improves neuronal dysfunction, and protects against glaucoma via down regulation of its target gene, 27/November/2017, 8.07 am 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from the The Jackson Laboratory, Bar Harbor, ME 04609, USA; Department of Ophthalmology, Tufts University of Medicine, Boston, MA 02111, USA; The Howard Hughes…

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Vitamin-based therapy for Non-alcoholic fatty liver disease (NAFLD): Calcitriol, a form of Vitamin-D, promotes degradation of HMGCR, decreases the levels of triglycerides, free cholesterol, and total cholesterol and prevents the progression of Non-alcoholic fatty liver disease (NAFLD via down regulation of its target gene, 27/September/2017, 6.31 am
Vitamin-based therapy for Non-alcoholic fatty liver disease (NAFLD): Calcitriol, a form of Vitamin-D, promotes degradation of HMGCR, decreases the levels of triglycerides, free cholesterol, and total cholesterol and prevents the progression of Non-alcoholic fatty liver disease (NAFLD via down regulation of its target gene, 27/September/2017, 6.31 am 960 720 Dr Boomi's Genom-2-Discovery Center

Significance of the study: Given that: (1)  15-30% of Western populations suffer from Non-alcoholic fatty liver disease (NAFLD), while only 6-25% of Asian populations suffer from it; (2) 75 to 100 million…

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Natural product therapy for pulmonary arterial hypertension: Schisandrin B, one of the main components of Schisandra chinensis/Magnolia Vine, inhibits the development of pulmonary arterial hypertension via down regulation of its target gene Notch3, 27/November/2017, 6.23 am
Natural product therapy for pulmonary arterial hypertension: Schisandrin B, one of the main components of Schisandra chinensis/Magnolia Vine, inhibits the development of pulmonary arterial hypertension via down regulation of its target gene Notch3, 27/November/2017, 6.23 am 960 720 Dr Boomi's Genom-2-Discovery Center

What they say:   A study from the University of California, La Jolla, California, USA shows that “Notch3 signaling promotes the development of pulmonary arterial hypertension.” This study was published, in the 15 November  2009 issue of the journal “Nature Medicine”[the number 1 journal in General…

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Activation of the PD-1 pathway for Pain therapy: Withaferin A, isolated from Ashwagantha/Withania Sominifera, increases the expression of PD-L1, attenuates acutes and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability via up-regulation of its target gene, 27/November/2017, 6.11 am
Activation of the PD-1 pathway for Pain therapy: Withaferin A, isolated from Ashwagantha/Withania Sominifera, increases the expression of PD-L1, attenuates acutes and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability via up-regulation of its target gene, 27/November/2017, 6.11 am 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction:What they say: A recent study from Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for Brain Science, Fudan University, Shanghai,…

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Natural product-based combination therapy targeting cancer stem cells in Myeloid leukaemia (ML): A therapeutic mix encompassing Pseudolaric acid B, Rosiglitazone, Ivermectin, Dacogen (PRID) inhibits cytosolic aminotransferase BCAT1 expression, increases a-ketoglutarate levels, promotes degradation of HIF1a levels, increases DNA demethylase levels, promotes hypomethylation, increases the expression of tumor suppressor genes, inhibits leukaemia-initiating potential of AML cells, promotes differentiation of AML cells, and inhibits cancer progression in AML via up-regulation of its target gene, 25/November/2017, 4.13 pm
Natural product-based combination therapy targeting cancer stem cells in Myeloid leukaemia (ML): A therapeutic mix encompassing Pseudolaric acid B, Rosiglitazone, Ivermectin, Dacogen (PRID) inhibits cytosolic aminotransferase BCAT1 expression, increases a-ketoglutarate levels, promotes degradation of HIF1a levels, increases DNA demethylase levels, promotes hypomethylation, increases the expression of tumor suppressor genes, inhibits leukaemia-initiating potential of AML cells, promotes differentiation of AML cells, and inhibits cancer progression in AML via up-regulation of its target gene, 25/November/2017, 4.13 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction to what they say: A study from the Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), 69120 Heidelberg, Germany; Division of Stem Cells and Cancer, German…

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Natural product therapy for body weight control, energy homeostasis and TIIDM:  Resveratrol, isolated from Polygonum Cuspidatum, grapes, ground nuts, among others,  decreases CADM1 and its downstream target genes that promote glucose-induced insulin secretion, improves insulin sensitivity, increases energy utilization, promotes weight loss and protects from diet-induced obesity and TIIDM via up regulation of its target gene, 25/November/2017, 4.06 pm
Natural product therapy for body weight control, energy homeostasis and TIIDM:  Resveratrol, isolated from Polygonum Cuspidatum, grapes, ground nuts, among others,  decreases CADM1 and its downstream target genes that promote glucose-induced insulin secretion, improves insulin sensitivity, increases energy utilization, promotes weight loss and protects from diet-induced obesity and TIIDM via up regulation of its target gene, 25/November/2017, 4.06 pm 960 720 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from the Max Delbrück Center for Molecular Medicine, Berlin, Germany shows that “Regulation of body weight and energy homeostasis by neuronal cell adhesion molecule1.”…

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