Ideas

August 4, 2019

Published by admin_auro at August 4, 2019

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Mechanistic insights into how Tofacitinib attenuates rheumatoid arthritis: Tofacitinib (brand name: Xeljanz), used to treat rheumatoid/psoriatic arthritis and ulcerative colitis, increases IL-9 levels, augments proliferation of ILC2s (type 2 innate lymphoid cells) and regulatory T (Treg) cells, promotes resolution of inflammation, attenuates cartilage destruction, decreases bone loss, and inhibits pathological features associated with arthritis via up-regulation of its target genes, 5/August/2018, 1.29 am

Introduction: What they say A study from Department of Internal Medicine 3-Rheumatology and Immunology, Friedrich Alexander University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Germany shows that […]

August 3, 2019

Published by admin_auro at August 3, 2019

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Cancer
Ideas

Probiotic-based chemotherapy targeting cancer stem cells and immune-inhibitory receptors in advanced ovarian cancer and other metastatic cancers: A pharmaceutical mixture encompassing Olaparib, an FDA-approved poly (adenosine diphosphate-ribose) polymerase inhibitor, and probiotic Lactobacillus rhamnosus increases the expression of tumor suppressor genes, such as FASLG, KLF5, p53, and TA-p73/p63, inhibits immune-inhibitory receptors/molecules, targets ovarian cancer stem cells, confers protection against chemoresistance and prolongs survival, via up-regulation of its target gene, 4/August/2019, 1.11 am

Introduction: What they say: A study from the Stephenson Cancer Center at the University of Oklahoma, Oklahoma City (K.M.), USA; University of Milan-Bicocca, European Institute of […]

August 2, 2019

Published by admin_auro at August 2, 2019

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Cancer
Ideas

Probiotic-based chemotherapy targeting cancer stem cells and immune-inhibitory receptors in chronic lymphocytic leukemia (CLL) and in advanced metastatic cancers: A pharmaceutical mixture encompassing Venetoclax and Ibrutinib (VAI) and probiotic Lactobacillus rhamnosus increases the expression of tumor suppressor genes, such as LZTFL1 (Leucine Zipper Transcription Factor Like 1), ACAT1 (Acetyl-CoA Acetyltransferase 1), p53, and TA-p73/p63, inhibits immune-inhibitory receptors/molecules, targets cancer stem cells, confers protection against chemoresistance and prolongs survival, and stalls CLL progression, via up-regulation of its target gene, 02/August/2019, 11.13 pm

Introduction: What they say A study from the University of Texas M.D. Anderson Cancer Center, Houston, USA shows that “Ibrutinib and Venetoclax for First-Line Treatment of CLL.” This research […]

August 1, 2019

Published by admin_auro at August 1, 2019

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Live longer by consuming polyamine-rich foods: Spermine-based Lifespan extension therapy: Spermine, one of the polyamines, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian lifespan by regulating the expression of its target genes, 1/August/2019, 11.29 pm

What they say: A study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal […]