Ideas

Cardiac rejuvenation therapy: Caveolin-1 (CAV1) suppresses tumor suppressor INK4a/p16 expression, and inhibits dilated cardiomyopathy and heart failure via up regulation of its target gene, 29/December/2016, 7.35 pm
Cardiac rejuvenation therapy: Caveolin-1 (CAV1) suppresses tumor suppressor INK4a/p16 expression, and inhibits dilated cardiomyopathy and heart failure via up regulation of its target gene, 29/December/2016, 7.35 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A recent study from the Stem Cell Aging Group, Centro Nacional de Investigaciones Cardiovasculares, E-28029 Madrid, Spain shows that “Bmi1 limits dilated cardiomyopathy and heart failure…

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Therapeutic insights into “awakening the sleeping/cancer-protecting angels” in mutant p53-expressing human tumors: Physcion 8-O-β-glucopyranoside, a major ingredient isolated from Radix et Rhizoma Rhei and and Rhubarb, increases the expression of tumor suppressor p53 homologue TA-p73/p63, PTEN, TPM1, TIMP3, BTG2, PDCD4, SPRY1/2 and CCM1/KRIT1 and induces regression of p53-mutated human tumors via down regulation of its target gene, 29/December/2016, 11.04 pm
Therapeutic insights into “awakening the sleeping/cancer-protecting angels” in mutant p53-expressing human tumors: Physcion 8-O-β-glucopyranoside, a major ingredient isolated from Radix et Rhizoma Rhei and and Rhubarb, increases the expression of tumor suppressor p53 homologue TA-p73/p63, PTEN, TPM1, TIMP3, BTG2, PDCD4, SPRY1/2 and CCM1/KRIT1 and induces regression of p53-mutated human tumors via down regulation of its target gene, 29/December/2016, 11.04 pm 150 150 Dr Boomi's Genom-2-Discovery Center

From Significance of the study to Public health relevance: Given that: (1) Cancer suppressor p53 is mutated in more than 50% of human cancers of different tissue origin; (2) p53…

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Natural product-derived Life-extension therapy: Isoliquiritigenin, isolated from Licorice (Glycyrrhiza glabra), inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 28/December/2016, 10. 48 pm
Natural product-derived Life-extension therapy: Isoliquiritigenin, isolated from Licorice (Glycyrrhiza glabra), inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 28/December/2016, 10. 48 pm 150 150 Dr Boomi's Genom-2-Discovery Center

What they say? A recent study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase…

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Molecular therapy for Myocardial Infarction: Methazolamide, a carbonic anhydrase inhibitor used in the treatment of glaucoma, inhibits DNA damage responses, increases telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction via up-regulation of PNUTS, 28/December/2016, 6.43 pm
Molecular therapy for Myocardial Infarction: Methazolamide, a carbonic anhydrase inhibitor used in the treatment of glaucoma, inhibits DNA damage responses, increases telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction via up-regulation of PNUTS, 28/December/2016, 6.43 pm 150 150 Dr Boomi's Genom-2-Discovery Center

What they say:  A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March  2013 issue of Nature  by Prof Dimmler, Boon, and others. What we…

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Therapeutic insights into “awakening the sleeping/cancer-protecting angels” in mutant p53-expressing human tumors: Paeoniflorin, a natural compound isolated from Paeonia lactiflora pall and Paeonia veitchii Lynch, increases the expression of tumor suppressor p53 homologue TA-p73/p63, PTEN, TPM1, TIMP3, BTG2, PDCD4, SPRY1/2 and CCM1/KRIT1 and induces regression of p53-mutated human tumors via down regulation of its target gene, 28/December/2016, 6.30 pm
Therapeutic insights into “awakening the sleeping/cancer-protecting angels” in mutant p53-expressing human tumors: Paeoniflorin, a natural compound isolated from Paeonia lactiflora pall and Paeonia veitchii Lynch, increases the expression of tumor suppressor p53 homologue TA-p73/p63, PTEN, TPM1, TIMP3, BTG2, PDCD4, SPRY1/2 and CCM1/KRIT1 and induces regression of p53-mutated human tumors via down regulation of its target gene, 28/December/2016, 6.30 pm 150 150 Dr Boomi's Genom-2-Discovery Center

From Significance of the study to Public health relevance: Given that: (1) Cancer suppressor p53 is mutated in more than 50% of human cancers of different tissue origin; (2) p53…

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Natural product-derived Life-extension therapy: Celastrol, found in the root extracts of Tripterygium wilfordii and Celastrus regelii, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 27/December/2016, 11. 45 pm
Natural product-derived Life-extension therapy: Celastrol, found in the root extracts of Tripterygium wilfordii and Celastrus regelii, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 27/December/2016, 11. 45 pm 150 150 Dr Boomi's Genom-2-Discovery Center

What they say? A recent study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase…

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