Ideas

September 6, 2017

Published by admin_auro at September 6, 2017

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Natural product-derived therapy for heart regeneration and repair: A pharmaceutical mixture encompassing Rivaroxaban and Sulforaphane increases Agrin expression, activates Yap and ERK-mediated signaling, replaces scar tissue with functional cardiomyocytes, and promotes cardiomyocyte regeneration and repair after myocardial infarction, via up regulation of its target gene, 7/September/2017, 12.05 am

Introduction: What they say: A recent study from Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel; Department of Biomedical Engineering, Duke University, […]

September 6, 2017

Published by admin_auro at September 6, 2017

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Molecular therapy for muscle atrophy and wasting:Ruxolitinib (Trade name: Jakavi/Jakafi), a drug used in the treatment of Myelofibrosis, increases the expression of FGF19 and its receptor ß-Klotho, phosphorylates ERK1/2 and S6K1, decreases the expression of tumor suppressors genes, promotes regeneration of muscle cells and hypertrophy of skeletal muscle, and reverses muscular atrophy and wasting via up regulation of its target gene, 6/September/2017, 11.57 pm

Introduction: What they say A study from Department of Biology, University of Bergen, Bergen, Norway; and Univ-Lyon, CarMeN Laboratory, INSERM 1060, INRA 1397, Université Claude Bernard Lyon, INSA Lyon, Oullins, France […]

September 6, 2017

Published by admin_auro at September 6, 2017

Categories

Cancer
Ideas

Molecular therapy for Metastatic cancers: Myrtenal, isolated from Taxus, increases the expression of context-dependent tumor suppressors Sox2 and IL1-β, inhibits cell cycle progression, and suppresses migration, invasion and metastasis of cancer cells via up regulation of its target gene, 6/September/2017, 11.42 pm

From Significance of the study to Public health relevance: Given that: (i) each year nearly 14 million people are diagnosed with cancer globally, and little more […]

September 5, 2017

Published by admin_auro at September 5, 2017

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Ideas
Pain

The PD-1 pathway activation for Pain therapy: Rivaroxaban, an anti-coagulant and a blood thinner, increases the expression of PD-L1, attenuates acutes and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability via up-regulation of its target gene, 6/september/2017, 12.28 am

Teacher’s day special ********* We wish everyone a happy Teacher’s day. On this special occasion, we are happy to announce that ideas posted today (05/September/2017) will be available to […]