Ideas

Molecular therapy for Myocardial Infarction: Verapamil, a calcium channel blocker and an antihypertensive drug, inhibits DNA damage responses, increases telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction via up-regulation of PNUTS, 25/December/2016, 11.19 pm
Molecular therapy for Myocardial Infarction: Verapamil, a calcium channel blocker and an antihypertensive drug, inhibits DNA damage responses, increases telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction via up-regulation of PNUTS, 25/December/2016, 11.19 pm 150 150 Dr Boomi's Genom-2-Discovery Center

What they say:  A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March  2013 issue of Nature  by Prof Dimmler, Boon, and others. What we…

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Natural product-derived PD-L1 pathway blockade enhances the efficacy of Cancer immunotherapy: Honokiol, isolated from Magnolia-grandiflora/dealbata/obovata/officinalis, inhibits the expression of PD-L1, inhibits inflammatory signalling and the number of tumor-infiltrating lymphocytes and macrophages, increases Cytotoxic activity of T-cells, decreases tumor burden and increases survival via up-regulation of its target gene, 25/December/2016, 10.37 pm
Natural product-derived PD-L1 pathway blockade enhances the efficacy of Cancer immunotherapy: Honokiol, isolated from Magnolia-grandiflora/dealbata/obovata/officinalis, inhibits the expression of PD-L1, inhibits inflammatory signalling and the number of tumor-infiltrating lymphocytes and macrophages, increases Cytotoxic activity of T-cells, decreases tumor burden and increases survival via up-regulation of its target gene, 25/December/2016, 10.37 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction:What they say: A recent study from Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Unit 108, 1515 Holcombe Boulevard, Houston, TX 77030, USA shows…

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Natural product-derived therapy for enhancing anti-cancer immunity: Emodin (6-methyl-1,3,8-trihydroxy anthraquinone), found in Polygonum multiflorum, decreases the level of LATS1/2 (large tumor suppressor 1 and 2), increases immunogenicity of tumors, enhances anti-tumor immune responses, and inhibits tumor growth via down regulation of its target gene, 25/December/2016, 10.00 pm
Natural product-derived therapy for enhancing anti-cancer immunity: Emodin (6-methyl-1,3,8-trihydroxy anthraquinone), found in Polygonum multiflorum, decreases the level of LATS1/2 (large tumor suppressor 1 and 2), increases immunogenicity of tumors, enhances anti-tumor immune responses, and inhibits tumor growth via down regulation of its target gene, 25/December/2016, 10.00 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say:  A study from the Department of Pharmacology and Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA shows that “The Hippo Pathway Kinases LATS1/2…

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Therapeutic insights into “awakening the sleeping/cancer-protecting angels” in mutant p53-expressing human tumors: PAPD5 (Poly(A) RNA Polymerase D5, Non-Canonical) increases the expression of tumor suppressor p53 homologue TA-p73/p63, PTEN, TPM1, TIMP3, BTG2, PDCD4, SPRY1/2 and CCM1/KRIT1 and induces regression of p53-mutated human tumors via down regulation of its target gene, 25/December/2016, 9.18 pm
Therapeutic insights into “awakening the sleeping/cancer-protecting angels” in mutant p53-expressing human tumors: PAPD5 (Poly(A) RNA Polymerase D5, Non-Canonical) increases the expression of tumor suppressor p53 homologue TA-p73/p63, PTEN, TPM1, TIMP3, BTG2, PDCD4, SPRY1/2 and CCM1/KRIT1 and induces regression of p53-mutated human tumors via down regulation of its target gene, 25/December/2016, 9.18 pm 150 150 Dr Boomi's Genom-2-Discovery Center

From Significance of the study to Public health relevance: Given that: (1) Cancer suppressor p53 is mutated in more than 50% of human cancers of different tissue origin; (2) p53…

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Natural product-derived therapy for Human Leukemias: Boehmenan, found in stem of Caulis clematidis armandii and Hibiscus ficulneus, suppresses B-Cell and myeloid leukemias via up regulation of the tumor suppressor IRF4, 25/December/2016, 12.03 am
Natural product-derived therapy for Human Leukemias: Boehmenan, found in stem of Caulis clematidis armandii and Hibiscus ficulneus, suppresses B-Cell and myeloid leukemias via up regulation of the tumor suppressor IRF4, 25/December/2016, 12.03 am 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say Noble laureate in Physiology/Medicine (1975) Prof. David Baltimore, from California Institute of Technology, California, USA, had reported in the July 8, 2014 issue of the Journal “Blood” that: “Dual mechanisms by which MiR-125b represses IRF4 to…

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Molecular therapy for Myocardial Infarction: KGF inhibits DNA damage responses, increases telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction via up-regulation of PNUTS, 24/December/2016, 11.35 pm
Molecular therapy for Myocardial Infarction: KGF inhibits DNA damage responses, increases telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction via up-regulation of PNUTS, 24/December/2016, 11.35 pm 150 150 Dr Boomi's Genom-2-Discovery Center

What they say:  A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March  2013 issue of Nature  by Prof Dimmler, Boon, and others. What we…

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