Ideas

Natural product-derived therapy for overcoming chemoresistance in Human cancers: Genistein increases the expression of CADM1, decreases BMI1 translocation, increases tumor suppressor INK4a/p16 expression and restores chemosensitivity in drug-resistant Human cancers via down regulation of its target gene, 16/December/2016, 10.35 pm
Natural product-derived therapy for overcoming chemoresistance in Human cancers: Genistein increases the expression of CADM1, decreases BMI1 translocation, increases tumor suppressor INK4a/p16 expression and restores chemosensitivity in drug-resistant Human cancers via down regulation of its target gene, 16/December/2016, 10.35 pm 150 150 Dr Boomi's Genom-2-Discovery Center

From Research findings to Therapeutic opportunity:  The study presented here suggests that Genistein, by increasing the expression of its target genes, it may: (i) increase the expression of CADM1; (ii) decrease BMI1 translocation; (iii) increase…

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Therapeutic insights into “awakening the sleeping/cancer-protecting angels” in mutant p53-expressing human tumors: MiR-29a increases the expression of tumor suppressor p53 homologue TA-p73/p63, PTEN, TPM1, TIMP3, BTG2, PDCD4, SPRY1/2 and CCM1/KRIT1 and induces regression of p53-mutated human tumors via down regulation of its target gene, 16/December/2016, 10.21 pm
Therapeutic insights into “awakening the sleeping/cancer-protecting angels” in mutant p53-expressing human tumors: MiR-29a increases the expression of tumor suppressor p53 homologue TA-p73/p63, PTEN, TPM1, TIMP3, BTG2, PDCD4, SPRY1/2 and CCM1/KRIT1 and induces regression of p53-mutated human tumors via down regulation of its target gene, 16/December/2016, 10.21 pm 150 150 Dr Boomi's Genom-2-Discovery Center

From Significance of the study to Public health relevance: Given that: (1) Cancer suppressor p53 is mutated in more than 50% of human cancers of different tissue origin; (2) p53…

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Anti-telomerase cancer therapy: MiR-188 suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and inhibits cancer progression via down-regulation of it target gene, 16/December/2016, 10.05 pm
Anti-telomerase cancer therapy: MiR-188 suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and inhibits cancer progression via down-regulation of it target gene, 16/December/2016, 10.05 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say:   The 1989 Nobel prize winner in Chemistry, Prof. Thomas R. Cech from the BioFrontiers Institute, USA has published a research paper in the 13 December 2012 issue of the Nature journal (492(7428):285-9; and I.F: >42) stating that “The TEL patch of telomere protein TPP1…

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Natural product-derived therapy for Human Leukemias: Thymoquinone, the most abundant component in Black Cumin– Nigella sativa and in Monarda Fistulosa, suppresses B-Cell and myeloid leukemias via up regulation of the tumor suppressor IRF4, 16/December/2016, 9.59 pm
Natural product-derived therapy for Human Leukemias: Thymoquinone, the most abundant component in Black Cumin– Nigella sativa and in Monarda Fistulosa, suppresses B-Cell and myeloid leukemias via up regulation of the tumor suppressor IRF4, 16/December/2016, 9.59 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say Noble laureate in Physiology/Medicine (1975) Prof. David Baltimore, from California Institute of Technology, California, USA, had reported in the July 8, 2014 issue of the Journal “Blood” that: “Dual mechanisms by which MiR-125b represses IRF4 to…

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Life-extension therapy: MiR-339-5p inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 16/December/2016, 9.41 pm
Life-extension therapy: MiR-339-5p inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 16/December/2016, 9.41 pm 150 150 Dr Boomi's Genom-2-Discovery Center

What they say? A recent study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase…

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Small molecule-based PD-1 pathway blockade for Human cancer therapy: Lithium increases transcription factor T-bet expression, decreases the abundance of co-inhibitory receptor PD-1 on the cell surface of Cytotoxic-T-cells, increases cytotoxic T lymphocyte function and augments anti-tumor activity, via up-regulation of its target gene, 16/December/2016, 1.21 pm
Small molecule-based PD-1 pathway blockade for Human cancer therapy: Lithium increases transcription factor T-bet expression, decreases the abundance of co-inhibitory receptor PD-1 on the cell surface of Cytotoxic-T-cells, increases cytotoxic T lymphocyte function and augments anti-tumor activity, via up-regulation of its target gene, 16/December/2016, 1.21 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction:What they say:  A recent study from Cell Signalling Section, Division of Immunology, Department of Pathology, Tennis Court Road, University of Cambridge, Cambridge CB2 1QP, UK shows that “Glycogen Synthase…

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