Ideas

Natural product-derived Lifespan extension therapy: Theobromine, isolated from Theobroma and commonly found in chocolates, increases life span via up-regulation of its target gene BubR1, 14/December/2016, 10.50 pm
Natural product-derived Lifespan extension therapy: Theobromine, isolated from Theobroma and commonly found in chocolates, increases life span via up-regulation of its target gene BubR1, 14/December/2016, 10.50 pm 150 150 Dr Boomi's Genom-2-Discovery Center

 What they say: Introduction:  A recent study from the Department of Genetics, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Harvard Medical School, Boston,USA; and Department of Pharmacology, School…

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Anti-telomerase cancer therapy: MiR-362-3p suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and inhibits cancer progression via down-regulation of it target gene, 14/December/2016, 10.36 pm
Anti-telomerase cancer therapy: MiR-362-3p suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and inhibits cancer progression via down-regulation of it target gene, 14/December/2016, 10.36 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say:   The 1989 Nobel prize winner in Chemistry, Prof. Thomas R. Cech from the BioFrontiers Institute, USA has published a research paper in the 13 December 2012 issue of the Nature journal (492(7428):285-9; and I.F: >42) stating that “The TEL patch of telomere protein TPP1…

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Life-extension therapy: MiRNA-7-3p inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 14/December/2016, 10.28 pm
Life-extension therapy: MiRNA-7-3p inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 14/December/2016, 10.28 pm 150 150 Dr Boomi's Genom-2-Discovery Center

What they say? A recent study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase…

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Natural product-derived therapy for Human Leukemias: Cucurbitacin E, found abundantly in Watermelons, suppresses B-Cell and myeloid leukemias via up regulation of the tumor suppressor IRF4, 14/December/2016, 10.19 pm
Natural product-derived therapy for Human Leukemias: Cucurbitacin E, found abundantly in Watermelons, suppresses B-Cell and myeloid leukemias via up regulation of the tumor suppressor IRF4, 14/December/2016, 10.19 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say Noble laureate in Physiology/Medicine (1975) Prof. David Baltimore, from California Institute of Technology, California, USA, had reported in the July 8, 2014 issue of the Journal “Blood” that: “Dual mechanisms by which MiR-125b represses IRF4 to…

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Anticancer therapy: MiRNA-9600 increases the expression of tumor suppressor protein Grainyhead transcription factor-3 (GRHL3), inhibits proliferation, and promotes apoptosis of cancer cells via down regulation of its target gene, 14/December/2016, 9.49 pm
Anticancer therapy: MiRNA-9600 increases the expression of tumor suppressor protein Grainyhead transcription factor-3 (GRHL3), inhibits proliferation, and promotes apoptosis of cancer cells via down regulation of its target gene, 14/December/2016, 9.49 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Research findings to Therapeutic opportunity:   The study presented here suggests that MiRNA-9600, by decreasing the expression of its target genes, it may increase the expression of tumor suppressor GRHL3. [easy_payment currency=”USD”] Thereby, it…

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Natural product-derived therapy for overcoming chemoresistance in Human cancers: Cirsilol (3′,4′,5-trihydroxy-6,7-dimethoxyflavone), a flavone isolated from Achillea fragrantissima, increases the expression of CADM1, decreases BMI1 translocation, increases tumor suppressor INK4a/p16 expression and restores chemosensitivity in drug-resistant Human cancers via down regulation of its target gene, 14/December/2016, 9.43 pm
Natural product-derived therapy for overcoming chemoresistance in Human cancers: Cirsilol (3′,4′,5-trihydroxy-6,7-dimethoxyflavone), a flavone isolated from Achillea fragrantissima, increases the expression of CADM1, decreases BMI1 translocation, increases tumor suppressor INK4a/p16 expression and restores chemosensitivity in drug-resistant Human cancers via down regulation of its target gene, 14/December/2016, 9.43 pm 150 150 Dr Boomi's Genom-2-Discovery Center

From Research findings to Therapeutic opportunity:  The study presented here suggests that Cirsiliol, by increasing the expression of its target genes, it may: (i) increase the expression of CADM1; (ii) decrease BMI1 translocation; (iii) increase…

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