Ideas

Small molecule-based PD-1 pathway blockade for Human cancer therapy: SMG7, a protein known to play a role in nonsense-mediated mRNA decay, inhibits the expression of co-inhibitory receptor PD-1 on Antigen- Specific T-cells, increases the production of cytokines by tumor-infiltrating lymphocytes (TIL), and draining lymph nodes and augments anti-tumor activity via down-regulation of its target gene, 18/December/2016, 10.29 pm
Small molecule-based PD-1 pathway blockade for Human cancer therapy: SMG7, a protein known to play a role in nonsense-mediated mRNA decay, inhibits the expression of co-inhibitory receptor PD-1 on Antigen- Specific T-cells, increases the production of cytokines by tumor-infiltrating lymphocytes (TIL), and draining lymph nodes and augments anti-tumor activity via down-regulation of its target gene, 18/December/2016, 10.29 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction:What they say: A recent study from Division of Infectious Diseases, School of Medicine, Johns Hopkins University, Baltimore, MD 21218, United States shows that “TGF-β1-Mediated Smad3 Enhances PD-1 Expression on…

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MiRNA-based PD-1 pathway blockade for Human cancer therapy: MiR-660 decreases the expression of Glycogen synthase kinase-3β, increases transcription factor T-bet expression, decreases the abundance of co-inhibitory receptor PD-1 on the cell surface of Cytotoxic-T-cells, increases cytotoxic T lymphocyte function and augments anti-tumor activity, via up-regulation of its target gene, 17/December/2016, 11.20 pm
MiRNA-based PD-1 pathway blockade for Human cancer therapy: MiR-660 decreases the expression of Glycogen synthase kinase-3β, increases transcription factor T-bet expression, decreases the abundance of co-inhibitory receptor PD-1 on the cell surface of Cytotoxic-T-cells, increases cytotoxic T lymphocyte function and augments anti-tumor activity, via up-regulation of its target gene, 17/December/2016, 11.20 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction:What they say:  A recent study from Cell Signalling Section, Division of Immunology, Department of Pathology, Tennis Court Road, University of Cambridge, Cambridge CB2 1QP, UK shows that “Glycogen Synthase…

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Therapeutic insights into “awakening the sleeping angel” in mutant p53-expressing human tumors: MiR-3666 increases the expression of tumor suppressor p53 homologue TAp73 and induces regression of p53-mutated human tumors via down regulation of its target gene, 17/December/2016, 11.14 pm
Therapeutic insights into “awakening the sleeping angel” in mutant p53-expressing human tumors: MiR-3666 increases the expression of tumor suppressor p53 homologue TAp73 and induces regression of p53-mutated human tumors via down regulation of its target gene, 17/December/2016, 11.14 pm 150 150 Dr Boomi's Genom-2-Discovery Center

From Significance of the study to Public health relevance: Given that: (1) Cancer suppressor p53 is mutated in more than 50% of human cancers of different tissue origin; (2) p53…

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Molecular therapy for triple-negative breast tumors: MiR-663 increases the levels of cell cycle inhibitor, p27, inhibits pro-survival pathways mediated by c-Myc, and inhibits the progression of triple-negative breast cancer via up-regulation of its target gene, 17/December/2016, 10.59 pm
Molecular therapy for triple-negative breast tumors: MiR-663 increases the levels of cell cycle inhibitor, p27, inhibits pro-survival pathways mediated by c-Myc, and inhibits the progression of triple-negative breast cancer via up-regulation of its target gene, 17/December/2016, 10.59 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from the Department of Cell and Tissue Biology, University of California, San Francisco (UCSF), San Francisco, California, USA shows that “PIM1 kinase inhibition as…

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Lifespan extension therapy: Amiodarone, an antiarrhythmic drug, decreases aging-related decline in muscle function and enhances the longevity of mammals via down regulation of Myostatin, 17/December/2016, 11.04 am
Lifespan extension therapy: Amiodarone, an antiarrhythmic drug, decreases aging-related decline in muscle function and enhances the longevity of mammals via down regulation of Myostatin, 17/December/2016, 11.04 am 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction:  A study from the Department of Orthopaedic Surgery, University of Michigan Medical School, USA; and Department of Molecular & Integrative Physiology, University of Michigan Medical School, USA shows that “Haploinsufficiency of myostatin protects against aging-related…

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Natural product-derived antiviral therapy against chikungunya (CHIKV) and Zika (ZIKV) viruses. γ-Bisabolene, one of the components in Cardamom, Cubeb, lemon, and Oregano among others, decreases spermidine/spermine N1-acetyltransferase (SAT) expression, depletes spermidine and Spermine levels, and restricts Chikungunya and Zika viruses replication via up regulation of its target gene, 17/December/2016, 10.19 am
Natural product-derived antiviral therapy against chikungunya (CHIKV) and Zika (ZIKV) viruses. γ-Bisabolene, one of the components in Cardamom, Cubeb, lemon, and Oregano among others, decreases spermidine/spermine N1-acetyltransferase (SAT) expression, depletes spermidine and Spermine levels, and restricts Chikungunya and Zika viruses replication via up regulation of its target gene, 17/December/2016, 10.19 am 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from the Viral Populations and Pathogenesis Unit, Institut Pasteur, CNRS UMR 3569, 25–28 rue du Dr. Roux, 75724 Paris Cedex 15, France shows that…

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