Natural product Immune enhancement therapy: (+)-Syringaresinol, isolated from Panax ginseng berry, and Prunus mume, among others, increases SOX2 expression and promotes innate immunity against bacterial infection via down-regulation of its target gene, 11/November/2016, 11.04 am

Introduction: What they say:  A recent study from the Institute of Biophysics, Chinese Academy of Sciences, Beijing, China shows that “Sox2 functions as a sequence-specific DNA sensor in neutrophils to initiate innate immunity against microbial infection.” This study was published in the 2 March 2015 issue of the Journal “Nature Immunology” [the number one journal in immunological research with an impact factor of  24.973] by Drs. […]

Small molecule-based therapy for Myocardial Infarction: Amifostine/Ethyol, a cytoprotective adjuvant, improves myocardial function after myocardial infarction via up-regulation of PNUTS, 14/November/2016, 10.55 am

What they say:  A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March  2013 issue of Nature  by Prof Dimmler, Boon, and others. What we say:  On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Small molecule-based therapy for Myocardial Infarction: Amifostine/Ethyol, a cytoprotective adjuvant, improves […]

Natural product-based anti-ageing therapy: Avicularin , found in Taxillus kaempferi, Rhododendron aureum, and Polygonum aviculare, among others, increases NMN levels, decreases age-associated weight gain, augments energy metabolism, improves physical activity and insulin sensitivity, promotes healthy lipid profile, and improves eye function via down regulation of its target gene, 13/November/2016, 1.13 pm

Introduction: What they say A study from Gladstone Institute of Neurological Disease and Department of Neurology, University of California, San Francisco, San Francisco, CA 94158, USA and Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA shows that Prolonged Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice. This […]

Natural product Life-span extension therapy: (+)-Syringaresinol, isolated from Panax ginseng berry, & Prunus mume, among others, increases life span by suppressing mTOR pathway through up regulation of its target gene, 13/November/2016, 11.26 am

What is known: It has been shown earlier that decreasing the expression/activity of mTOR increases overall mammalian lifespan, suggesting that mTOR inhibitors may function as “longevity promoters” From research findings to therapeutic opportunity:  This study suggests, for the first time, that (+)-Syringaresinol, by increasing the expression of its target gene, it may suppress the expression of mTOR. […]

Natural product therapy for KRAS-mutant lung cancer: Epigallocatechin gallate, one of the main components of Green tea, decreases the expression of XPO1, increases the level of NFKBIA, inhibits NFKB transcriptional activity and suppresses the progression of KRAS-mutant lung cancer via up regulation of its target gene, 13/November/2016, 9.20 am

What they say:  A recent study from the Department of Cell Biology, University of Texas Southwestern Medical Center, Texas 75390, USA shows that XPO1 can be pharmacologically targeted in KRAS-mutant lung cancer. This study was published in the 28 September 2016 issue of Nature by Prof Michael A.White, Kim, and others. What we say:  On the foundation […]

MiRNA-based therapy for Breast Cancer: MiRNA-137 increases the level of tumor suppressor p53, inhibits the proliferation of tumor-initiating cells in breast cancer, suppresses the progression of metastatic breast cancer, and supports tumor relapse-free survival in breast cancer patients, 13/November/2015, 9.01 am

What they say:  A study from the Division of Molecular Medicine and Genetics, Department of Internal Medicine, The Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, USA shows that “Snail1-dependent p53 repression regulates expansion and activity of tumour-initiating cells in breast cancer” This study was published in the 17 October 2016 issue of […]