Ideas

Natural product therapy for triple-negative breast tumors: Isoliquiritigenin, found in Licorice, increases the levels of cell cycle inhibitor, p27, inhibits pro-survival pathways mediated by c-Myc, and inhibits the progression of triple-negative breast cancer via up-regulation of its target gene, 15/November/2015, 10.02 pm
Natural product therapy for triple-negative breast tumors: Isoliquiritigenin, found in Licorice, increases the levels of cell cycle inhibitor, p27, inhibits pro-survival pathways mediated by c-Myc, and inhibits the progression of triple-negative breast cancer via up-regulation of its target gene, 15/November/2015, 10.02 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from the Department of Cell and Tissue Biology, University of California, San Francisco (UCSF), San Francisco, California, USA shows that “PIM1 kinase inhibition as…

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Natural product therapy for KRAS-mutant lung cancer: Grifolin, an antitumor natural product from the mushroom Albatrellus confluens, decreases the expression of XPO1, increases the level of NFKBIA, inhibits NFKB transcriptional activity and suppresses the progression of KRAS-mutant lung cancer via up regulation of its target gene, 15/November/2016, 9.31 pm
Natural product therapy for KRAS-mutant lung cancer: Grifolin, an antitumor natural product from the mushroom Albatrellus confluens, decreases the expression of XPO1, increases the level of NFKBIA, inhibits NFKB transcriptional activity and suppresses the progression of KRAS-mutant lung cancer via up regulation of its target gene, 15/November/2016, 9.31 pm 150 150 Dr Boomi's Genom-2-Discovery Center

What they say:  A recent study from the Department of Cell Biology, University of Texas Southwestern Medical Center, Texas 75390, USA shows that XPO1 can be pharmacologically targeted in KRAS-mutant lung cancer.…

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Natural product therapy for Breast Cancer: Kukoamine A (KuA), a spermine alkaloid derived from Cortex lycii radicis and Lycium chinense among others, increases the levels of tumor suppressor p53, decreases the expression of metastasis promoter Snail1, inhibits the proliferation of tumor-initiating cells, suppresses epithelial-to-mesenchymal transition and the progression of metastasis, and supports tumor relapse-free survival in breast cancer patients, 15/November/2015, 1.04 pm
Natural product therapy for Breast Cancer: Kukoamine A (KuA), a spermine alkaloid derived from Cortex lycii radicis and Lycium chinense among others, increases the levels of tumor suppressor p53, decreases the expression of metastasis promoter Snail1, inhibits the proliferation of tumor-initiating cells, suppresses epithelial-to-mesenchymal transition and the progression of metastasis, and supports tumor relapse-free survival in breast cancer patients, 15/November/2015, 1.04 pm 150 150 Dr Boomi's Genom-2-Discovery Center

What they say:  A study from the Division of Molecular Medicine and Genetics, Department of Internal Medicine, The Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, USA shows…

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Natural product therapy for glucose homeostasis and TIIDM: Kaempferol, found in Allium cepa, Aloe vera, Coccinia grandis, Moringa oleifera & Rosmarinus officinalis among others, increases IKKß and XBP1s activity, decreases the levels of tumor suppressor/stress-responsive proteins, such as PDCD4, and PTEN, reduces ER stress, improves insulin sensitivity, promotes glucose homeostasis and prevents the progression of TIIDM via up regulation of its target gene, 15/November/2015, 12.03 pm
Natural product therapy for glucose homeostasis and TIIDM: Kaempferol, found in Allium cepa, Aloe vera, Coccinia grandis, Moringa oleifera & Rosmarinus officinalis among others, increases IKKß and XBP1s activity, decreases the levels of tumor suppressor/stress-responsive proteins, such as PDCD4, and PTEN, reduces ER stress, improves insulin sensitivity, promotes glucose homeostasis and prevents the progression of TIIDM via up regulation of its target gene, 15/November/2015, 12.03 pm 150 150 Dr Boomi's Genom-2-Discovery Center

What they say:  A study from the Division of Endocrinology, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02130, USA; Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology,…

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Natural product-based anti-ageing therapy: Hesperidin, found in Citrus fruits, increases NMN levels, decreases age-associated weight gain, augments energy metabolism, improves physical activity and insulin sensitivity, promotes healthy lipid profile, and improves eye function via down regulation of its target gene, 14/November/2015, 10.52 pm
Natural product-based anti-ageing therapy: Hesperidin, found in Citrus fruits, increases NMN levels, decreases age-associated weight gain, augments energy metabolism, improves physical activity and insulin sensitivity, promotes healthy lipid profile, and improves eye function via down regulation of its target gene, 14/November/2015, 10.52 pm 774 500 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say A study from Gladstone Institute of Neurological Disease and Department of Neurology, University of California, San Francisco, San Francisco, CA 94158, USA and Department of Developmental…

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Natural product therapy for tuberculosis: Eriocitrin, found in lemons, increases the expression of MKP-1, inhibits TLR2 signalling, secretion of Chemokine CXCL5, and recruitment of polymorphonuclear leukocytes (PMNs), decreases destructive pulmonary inflammation, promotes M. tuberculosis clearance and inhibits pulmonary tuberculosis via up-regulation of its target gene, 14/November/2016, 10.36 pm
Natural product therapy for tuberculosis: Eriocitrin, found in lemons, increases the expression of MKP-1, inhibits TLR2 signalling, secretion of Chemokine CXCL5, and recruitment of polymorphonuclear leukocytes (PMNs), decreases destructive pulmonary inflammation, promotes M. tuberculosis clearance and inhibits pulmonary tuberculosis via up-regulation of its target gene, 14/November/2016, 10.36 pm 150 150 Dr Boomi's Genom-2-Discovery Center

Introduction: What they say:  A study from the Max Plank Institute for Infection Biology, Berlin, Germany shows that “CXCL5-secreting pulmonary epithelial cells drive destructive neutrophilic inflammation in tuberculosis.” This study was…

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