Natural product Anti-telomerase cancer therapy: Moringa oleifera (MO) extract suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and inhibits cancer progression via down-regulation of its target gene, 22/October/2016, 7.05 am

The 1989 Nobel prize winner in Chemistry, Prof. Thomas R. Cech from the BioFrontiers Institute, USA has published a research paper in the 13 December 2012 Nature (492(7428):285-9; and I.F: >42) stating that “The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity.”  This study provides mechanistic insights into how TPP1 regulates telomerase function. In connection with this finding, Dr Boominathan, Founder Director-cum-chief scientist of GBMD, reports that: Natural product Anti-telomerase cancer therapy: Moringa oleifera (MO) extract suppresses the […]

MiRNA therapy for Myocardial dysfunction: MiR-765 increases CDK inhibitor p27 expression, inhibits mTOR pathway, promotes autophagy in myocardial cells and prevents myocardial dysfunction via down-regulation of its target gene, 22/October/2016, 6.51 am

Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports here that: MiRNA therapy for Myocardial dysfunction: MiR-765 increases CDK inhibitor p27 expression, inhibits mTOR pathway, promotes autophagy in myocardial cells and prevents myocardial dysfunction via down-regulation of its target gene Significance: Given that: (1)  cardiovascular disease is the leading cause of death worldwide; (2) in India, in […]

Natural product therapy for tuberculosis: Fructus Ligustri Lucide extract increases the expression of MKP-1, inhibits TLR2 signalling, secretion of Chemokine CXCL5, and recruitment of polymorphonuclear leukocytes (PMNs), decreases destructive pulmonary inflammation , promotes M. tuberculosis clearance and inhibits pulmonary tuberculosis via up-regulation of its target gene, 21/October/2016, 5.03 pm

A study from the Max Plank Institute for Infection Biology, Berlin, Germany shows that “CXCL5-secreting pulmonary epithelial cells drive destructive neutrophilic inflammation in tuberculosis.” This study was published in the 10 February 2014 issue of the“Journal of Clinical Investigation” [One of the best research journals in clinical medicine with an impact factor of 12.575] by […]

Natural product therapy for aged patients with Myocardial Infarction: Berberine, an isoquinoline alkaloid isolated from Phellodendron amurense, and Tinospora cordifolia, induces autophagy in cardiomyocytes, inhibits cardiomyocyte hypertrophy, improves myocardial function in Post myocardial-infarction patients via up-regulation of PPAR-α, PNUTS/PPP1R10 and Sirutin1, 21/October/2016, 1.31 pm

A recent study from the Institute of Molecular and Translational Therapeutic Strategies, Hannover Medical School, Hannover, Germany; Excellence Cluster REBIRTH, Hannover Medical School, Hannover, Germany; and National Heart and Lung Institute, Imperial College, London, United Kingdom shows that “Preclinical Development of a MicroRNA-Based Therapy for Elderly Patients With Myocardial Infarction.” This study was published in […]

Natural product anti-inflammatory therapy for upper respiratory tract inflammatory diseases: Hyperoside, found in Drosera Rotundifolia and Prunella vulgaris (Common self-heal), increases the expression of negative regulator of inflammation MyD88(s), inhibits pro-inflammatory mediators in lungs, and alleviates the common respiratory pathogen nontypeable Haemophilus influenzae (NTHi)-exacerbated asthma & chronic obstructive pulmonary disease via up-regulation of its target gene, 21/October/2015, 7.55 am

A study from the Center for Inflammation, Immunity &Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA, 30303, USA shows that: “Resveratrol suppresses NTHi-induced inflammation via up-regulation of the negative regulator MyD88 short.” This study was published in the 28 September 2016 issue of the journal “Scientific reports” by Prof. Li JD, Andrews CS […]

Molecular therapy for Myocardial dysfunction: Metformin, one of the widely used drugs in the treatment of TIIDM, increases CDK inhibitor p27 expression, inhibits mTOR pathway, promotes autophagy in myocardial cells and prevents myocardial dysfunction via down-regulation of its target gene, 21/October/2016, 6.15 am

Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports here that: Molecular therapy for Myocardial dysfunction: Metformin, one of the widely used drugs in the treatment of TIIDM, increases CDK inhibitor p27 expression, inhibits mTOR pathway, promotes autophagy in myocardial cells and prevents myocardial dysfunction via down-regulation of its target gene Significance: Given that: (1)  cardiovascular disease […]