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Ideas

February 5, 2017

Immune enhancement therapy: Gremlin-1 (GREM1) increases SOX2 expression and promotes innate immunity against bacterial infection via down-regulation of its target gene, 5/February/2017, 7.24 pm

Introduction: What they say:   A recent study from the Institute of Biophysics, Chinese Academy of Sciences, Beijing, China shows that “Sox2 functions as a sequence-specific DNA sensor in […]
February 5, 2017

Natural product-based Lifespan extension therapy: Casticin, found in VITEX agnus-castus, prolongs mammalian life span via down regulation of angiotensin II type I receptor (AT1R), 5/February/2017, 7.00 pm

Significance of the study: It has been shown earlier that antagonizing angiotensin II type I receptor (AT1R) expression may prolong mammalian life span. Further, it has been shown […]
February 5, 2017

Life-extension therapy: Orphan nuclear receptor Nur77/NGFI-B inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 5/February/2017, 6.47 pm

What they say?  A study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal […]
February 5, 2017

Natural product-based therapy for Metastatic tumors: Formononetin, an isoflavone found in the roots of astragalus membranaceus, Trifolium pratense, Glycyrrhiza glabra, and Pueraria lobata, increases the expression of tumor suppressor gene PDCD4 and promotes apoptosis of tumor cells via down regulation of its target gene, 5/February/2017, 6.23 pm

From Significance of the study to Public health relevance:  Given that: (1) Cancer suppressor p53 is mutated in more than 50% of human cancers of different […]
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