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Ideas

February 4, 2017

Natural product-based therapy for Metastatic tumors: Formononetin, an isoflavone found in the roots of astragalus membranaceus, Trifolium pratense, Glycyrrhiza glabra, and Pueraria lobata, increases the expression of tumor suppressor gene BTG2 and inhibits invasion, migration and metastasis of tumor cells via down regulation of its target gene, 4/February/2017, 4.07 pm

From Significance of the study to Public health relevance:  Given that: (1) Cancer suppressor p53 is mutated in more than 50% of human cancers of different […]
February 4, 2017

Natural product-derived therapy for Human Leukemias: Casuarinin, a hydrolyzable tannin isolated from the bark of Terminalia arjuna Linn. (Combretaceae), suppresses B-Cell and myeloid leukemias via up regulation of the tumor suppressor IRF4, 4/February/2017, 7.20 am

Introduction: What they say Noble laureate in Physiology/Medicine (1975) Prof. David Baltimore, from California Institute of Technology, California, USA, had reported in the July 8, 2014 issue of the Journal “Blood” that: “Dual mechanisms […]
February 4, 2017

Anti-telomerase cancer therapy: Gastrokine-1 suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and the cellular immortality gene telomerase and inhibits cancer progression via down-regulation of it target gene, 4/February/2017, 6.33 am

Introduction: What they say:   The 1989 Nobel prize winner in Chemistry, Prof. Thomas R. Cech from the BioFrontiers Institute, USA has published a research paper in the 13 December 2012 issue of the Nature journal (492(7428):285-9; and I.F: >42) stating that “The TEL […]
February 3, 2017

Natural product-based Lifespan extension therapy: Piper betle leaf (PBLs) prolongs mammalian life span via down regulation of angiotensin II type I receptor (AT1R), 3/February/2017, 11.36 pm

Significance of the study: It has been shown earlier that antagonizing angiotensin II type I receptor (AT1R) expression may prolong mammalian life span. Further, it has been shown […]
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