Ideas

February 24, 2017

Natural product-derived Anti-AXL therapeutics for enhancing the efficacy of chemotherapies: Combination of Diallyl trisulfide and Baicalein, found in Garlic and Scutellaria baicalensis, respectively, decreases the expression of the AXL receptor and its activating ligand, GAS6, increases the expression of a number of tumor suppressor genes, increases therapeutic index of anticancer drugs, suppresses tumorigenesis, migration, invasion, and metastasis via up regulation of its target gene, 24/February/2017, 6.04 am

Introduction: What they say: A study from the Department of Radiation Oncology, Stanford University School of Medicine shows that “Inhibition of the GAS6/AXL pathway augments the […]
February 23, 2017

Natural product-derived therapy for glucose homeostasis and TIIDM: Morin (3,5,7,2′,4′-pentahydroxyflavone), found in Maclura pomifera (Osage orange), Maclura tinctoria (old fustic) and leaves of Psidium guajava (common guava), increases Pax6 and insulin expression, decreases the levels of glucagon, ghrelin and Somatostatin, reduces metabolic stress, improves insulin sensitivity, promotes glucose homeostasis and prevents progression to TIIDM via down regulation of their target gene, 23/February/2017, 11.49 pm

Introduction: What they say  A study from the Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, […]
February 23, 2017

Natural product-derived Anti-AXL therapeutics for enhancing the efficacy of chemotherapies: Combination of Valproic acid and Deoxycholic acid, decreases the expression of the AXL receptor and its activating ligand, GAS6, increases the expression of a number of tumor suppressor genes, increases therapeutic index of anticancer drugs, suppresses tumorigenesis, migration, invasion, and metastasis via up regulation of its target gene, 23/February/2017, 10.38 pm

Introduction: What they say: A study from the Department of Radiation Oncology, Stanford University School of Medicine shows that “Inhibition of the GAS6/AXL pathway augments the […]
February 23, 2017

Natural product-derived antiviral therapy for HIV virus: Shikonin, isolated from Zicao (also known as Purple gromwell, the dried root of Lithospermum erythrorhizon), increases Heme oxygenase 2 (HO-2) expression, blocks N-myristoylation of HIV-1 Gag protein, disrupts HIV-1 budding, and restricts HIV-1 production via up regulation of its target gene, 23/February/2017, 9.53 pm

Introduction: What they say A study from the Department of Biochemistry and Molecular Biophysics and Department of Microbiology and Immunology, Howard Hughes Medical Institute, Columbia University, […]
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