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Ideas

January 5, 2017

Natural product-derived regenerative therapy for improving muscle repair and strength in the elderly: Honokiol, isolated from Magnolia-grandiflora/dealbata/obovata/officinalis, decreases the expression of HOXA9, increases skeletal muscle regeneration and improves muscle stem cells function and repair via up regulation of its target genes, 5/January/2016, 2.40 pm

Introduction: What they say A study from Faculty of Medicine, Friedrich-Schiller-University, Germany shows that “Epigenetic stress responses induce muscle stem-cell ageing by Hoxa9 developmental signals.” This […]
January 5, 2017

Natural product-derived therapy for enhancing anti-cancer immunity: Withaferin A, one of the main components of Acnistus arborescens, and Ashwagantha among others, decreases the level of LATS1/2 (large tumor suppressor 1 and 2), increases immunogenicity of tumors, enhances anti-tumor immune responses, and inhibits tumor growth via down regulation of its target gene, 5/January/2017, 11.42 am

Introduction: What they say:  A study from the Department of Pharmacology and Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA shows that […]
January 4, 2017

Vitamin-based therapy for triple-negative breast tumors: 1α,25-dihydroxyvitamin D(3)/Calcitriol increases the levels of cell cycle inhibitor, p27, inhibits pro-survival pathways mediated by c-Myc, and inhibits the progression of triple-negative breast cancer via up-regulation of its target gene, 4/January/2017, 10.15 pm

Introduction: What they say A study from the Department of Cell and Tissue Biology, University of California, San Francisco (UCSF), San Francisco, California, USA shows that […]
January 4, 2017

Natural product-derived combination therapy for augmenting the anti-cancer drug 5-FU (5-Flurouracil) sensitivity in Human cancers: Bergapten (5-methoxypsoralen), a natural psoralen derivative present in many fruits and vegetables, decreases the expression of the rate-limiting enzyme of the ‘uracil catabolic pathway’ Dihydropyrimidine dehydrogenase (DPYD), increases 5-FU accumulation in cancer cells, augments chemosensitivity, and anti-tumor effect via upregulation of its target gene, 4/January/2017, 10.01 pm

From Research findings to Therapeutic opportunity:  The study presented here suggests that Bergapten (5-methoxypsoralen), by increasing the expression of its target genes, it may: (i) decrease the expression […]
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