Molecular cancer therapy: JunB inhibits cancer development by suppressing the expression of nucleotide sanitizing enzyme MTH1/NUDT1, 26/April/2015, 17.16

A study from Karolinska Institutet, Stockholm, Sweden shows that MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool.  This study was published in the April 10, 2014 Nature [I.F >42] by Prof. Thomas H, Dr Gad H and others from Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden. On the foundation of this interesting […]

MiRNA-based therapy for Preserving β-Cell functioning in DM and for extending life span of humans: MiRNA-137 increases the expression of antiaging and longevity gene Klotho, improves β-Cell function and prevents the development of T2DM via down regulation of its target gene, 24/April/2015, 23.55

Significance:   Given that (1)  more than 387 million people worldwide are affected by Diabetes mellitus (DM); (2) the life-long painful injection/drug treatment is required to treat DM; and (3) the global economic cost spent for diabetes treatment in 2014 was little more than 600 billion US dollars, there is an urgent need to find: (i)  a way […]

Sunlight exposure stalls p53-mutated metastatic cancer progression: Calcitriol (1α, 25-dihydroxyvitamin D3) increases the expression of tumor suppressor p53 homolouge TAp63 and inhibits migration and invasion of metastatic cancer cells via down regulation of its target gene, 19/April/2015, 10.43 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Significance:  Cancer suppressor p53 is mutated in more than 50% of human cancers of different origin, while its pathway is altered in about 80% of tumors. This study suggests a therapeutic strategy as to how p53-deficient or mutant p53 expressing human cancers can be cured by activating its “homologous protein […]

Natural product-based cancer therapy: Ursolic acid, enriched in apples, inhibits cancer development by suppressing the expression of nucleotide sanitizing enzyme MTH1/NUDT1, 5/April/2015, 14.23

A study from Karolinska Institutet, Stockholm, Sweden shows that “MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool.” This study was published in the April 10, 2014 Nature [I.F >42] by Prof. Thomas H, Dr Gad H and others from Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden. On the foundation of […]

Natural product-based Lifespan extension therapy: Piceatannol, a natural compound found in passion fruit (Passiflora edulis), may prolong mammalian life span via down regulation of angiotensin II type I receptor (AT1R), 1/April/2014, 22.03

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, L., Natural product-based Lifespan extension therapy: Piceatannol, a natural compound found in passion fruit (Passiflora edulis), may prolong mammalian life span via down regulation of angiotensin II type I receptor (AT1R), 1/April/2014, 22.03, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Web: http://genomediscovery.org Courtesy: When you cite drop us a line at info@genomediscovery.org * Research cooperation Significance: It […]

Natural-product based therapy for Sepsis: Piceatannol, a natural compound found in passion fruit (Passiflora edulis), inhibits lung inflammation by inhibiting inflammasome activation pathway, 20/March/2014, 09.27 am

Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, Natural-product based therapy for Sepsis:  Piceatannol,  a natural compound found in passion fruit (Passiflora edulis),  inhibits lung inflammation by inhibiting inflammasome activation pathway, 20/March/2014, 09.27 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Web: http://genomediscovery.org Courtesy: When you cite drop us a line at info@genomediscovery.org * Research cooperation Significance: Uncontrolled/excessive inflammation is the principle cause of  tissue damage […]