Small molecule-based Lifespan extension therapy: ZOCOR, a lipid lowering agent, increases mammalian life span via down regulation of angiotensin II type I receptor (AT1R), 14/June/2014, 9.33 am
Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, L., Small molecule-based Lifespan extension therapy:ZOCOR, a lipid lowering agent, increases mammalian life span via down regulation of angiotensin II type I receptor (AT1R), 14/June/2014, 9.33 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Web: http://genomediscovery.org Courtesy: When you cite drop us a line at info@genomediscovery.org * Research cooperation Significance: It has been shown earlier that angiotensin […]
Regenerating the lost pancreatic β-cells in TIDM patients: G-CSF (Granulocyte colony-stimulating factor) increases insulin-secreting cell mass and function via up regulation of its target genes, 14/June/2015, 12.00 pm
Idea Proposed/Formulated by: Dr L Boominathan Ph.D. Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/ Citation: Boominathan, Regenerating the lost pancreatic β-cells in TIDM patients: G-CSF (Granulocyte colony-stimulating factor) increases insulin-secreting cell mass and function via up regulation of its target genes, 14/June/2015, 12.00 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org Significance: Given that (1) more than 387 million people worldwide are affected by Diabetes mellitus (DM); (2) the life-long […]
Natural product-based Regenerative Stem cell therapy for Myocardial Infarction: Panax ginseng improves myocardial function after myocardial infarction via up regulation of PNUTS/PPP1R10 (Serine/threonine-protein phosphatase 1 regulatory subunit 10), 14/June/2015, 7.20 am
A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March 2013 issue of Nature by Prof Dimmler, Boon, and others. On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product–based Regenerative Stem cell therapy for Myocardial Infarction: Kaempherol improves myocardial function after myocardial infarction via up regulation […]
Molecular therapy for metastatic breast cancer: Tumor suppressor Grhl3 blocks bone metastasis of mammary cancer via down regulation of its target gene, 13/June/2015, 11.12 pm
A study from the Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen, Denmark; and Hypoxia and Metastasis Team, Cancer Research UK Tumour Cell Signalling Unit, The Institute of Cancer Research, London SW3 6JB, UK shows that “The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase.” This study was published in the 27 May 2015 issue of the journal “Nature” [the number […]
Natural product-based therapy for Cardiomyopathy: Oleic acid , the main component of neem oil, induces the expression of Trbp/miR-208, restores the balance between slow- and fast-twitch myofiber proteins and alleviates Cardiomyopathy via up regulation of its target gene, 12/June/2015, 9.01 am
A recent study from the Department of Cardiology, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, USA; and Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, USA shows that “Trbp regulates heart function through microRNA-mediated Sox6 repression.”This study was published in the 2 June 2015 issue of the journal “Nature Genetics” (the number 1 research journal in Genetics with an […]
Molecular therapy for NIDDM: Pitx2 inhibits gluconeogenesis and hyperglycemia via up regulation of Cyclin D1, Genome-2-Bio-Medicine Discovery center (GBMD), 11/06/2014, 8.40 am
A study from the Department of Cancer Biology, Dana-Farber Cancer Institute; Department of Cell Biology, Harvard Medical School, USA; and others shows that “Cyclin D1–Cdk4 controls glucose metabolism independently of cell cycle progression.” This study was published in the June 26, 2014 Nature [I.F >35] by Prof. Puigserver and others from the Department of Cancer Biology, Dana-Farber Cancer Institute; Department of Cell Biology, Harvard Medical School, USA. On the foundation of this interesting […]