Ideas

February 28, 2019

Probiotics-based immune enhancement therapy: A Probiotic mixture encompassing Lactobacillus plantarum KY1032 and Lactobacillus curvatus HY7601 (LBLC) increases SOX2 expression, and promotes innate immunity against bacterial infection, via down-regulation of its target gene, 28/February/2019, 8.46 am

Probiotics-based immune enhancement therapy: A Probiotic mixture encompassing Lactobacillus plantarum KY1032 and Lactobacillus curvatus HY7601 (LBLC) increases SOX2 expression, and promotes innate immunity against bacterial infection, via down-regulation of its target gene, 28/February/2019, 8.46 am https://genomediscovery.org/wp-content/uploads/2019/02/A-Probiotic-mixture-consisting-of-Lactobacillus-plantarum-Lactobacillus-curvatus-promotes-innate-immunity-against-bacterial-infections-through-induction-of-Sox2.jpg 960 720 Dr Boomi's Genom-2-Discovery Center Dr Boomi's Genom-2-Discovery Center https://genomediscovery.org/wp-content/uploads/2019/02/A-Probiotic-mixture-consisting-of-Lactobacillus-plantarum-Lactobacillus-curvatus-promotes-innate-immunity-against-bacterial-infections-through-induction-of-Sox2.jpg February 28, 2019 February 28, 2019

National Science day special ********* We wish everyone a very happy national science day. On this special occasion, we are happy to announce that Bio-Med/Pharma/Therapeutic/Clinical ideas posted today (28/February/2019) will be…

February 28, 2019

Probiotic Bacillus subtilis B10-based antiviral therapy for chikungunya (CHIKV) and Zika (ZIKV) viruses: Probiotic Lactobacillus Rhamnosus increases spermidine/spermine N1-acetyltransferase (SAT) expression, depletes spermidine and Spermine levels, and restricts Chikungunya and Zika viruses replication via upregulation of its target gene, 28/February/2019, 8.35 am

Probiotic Bacillus subtilis B10-based antiviral therapy for chikungunya (CHIKV) and Zika (ZIKV) viruses: Probiotic Lactobacillus Rhamnosus increases spermidine/spermine N1-acetyltransferase (SAT) expression, depletes spermidine and Spermine levels, and restricts Chikungunya and Zika viruses replication via upregulation of its target gene, 28/February/2019, 8.35 am https://genomediscovery.org/wp-content/uploads/2019/02/Probiotic-Bacillus-subtilis-B10-inhibits-CHIKV-and-ZIKV-replication-through-induction-of-Spermidine.spermine-N1acetyltransferase2.jpg 960 720 Dr Boomi's Genom-2-Discovery Center Dr Boomi's Genom-2-Discovery Center https://genomediscovery.org/wp-content/uploads/2019/02/Probiotic-Bacillus-subtilis-B10-inhibits-CHIKV-and-ZIKV-replication-through-induction-of-Spermidine.spermine-N1acetyltransferase2.jpg February 28, 2019 February 28, 2019

February 28, 2019

Combinatorial anti-cancer therapy blocking GPC2 pathway and immune receptors enhances the efficacy of Cancer immunotherapy in Neuroblastoma: A therapeutic mix encompassing Metformin, Navitoclax/ABT-263, Dasatinib and 2-Deoxy-d-glucose (MNDDG) inhibits the expression of GPC2, increases IFNγ signalling, increases antigen presentation and unfolding response, increases Cytotoxic activity of T-cells, inhibits neuroblastoma proliferation, decreases tumor burden and increases survival via up-regulation of its target gene, 28/February/2019, 8.23 am

Combinatorial anti-cancer therapy blocking GPC2 pathway and immune receptors enhances the efficacy of Cancer immunotherapy in Neuroblastoma: A therapeutic mix encompassing Metformin, Navitoclax/ABT-263, Dasatinib and 2-Deoxy-d-glucose (MNDDG) inhibits the expression of GPC2, increases IFNγ signalling, increases antigen presentation and unfolding response, increases Cytotoxic activity of T-cells, inhibits neuroblastoma proliferation, decreases tumor burden and increases survival via up-regulation of its target gene, 28/February/2019, 8.23 am https://genomediscovery.org/wp-content/uploads/2019/02/A-pharmaceutical-mixture-encompassing-Metformin-Navitoclax-Dasatinib-and-2deoxydglucose-MNDDG-inhibits-GPC2Glypican-2-expression-and-enhances-the-efficacy-of-cancer-immuotherapy-in-Neuroblastoma.jpg 960 720 Dr Boomi's Genom-2-Discovery Center Dr Boomi's Genom-2-Discovery Center https://genomediscovery.org/wp-content/uploads/2019/02/A-pharmaceutical-mixture-encompassing-Metformin-Navitoclax-Dasatinib-and-2deoxydglucose-MNDDG-inhibits-GPC2Glypican-2-expression-and-enhances-the-efficacy-of-cancer-immuotherapy-in-Neuroblastoma.jpg February 28, 2019 February 28, 2019

February 28, 2019

Probiotics function as anti-HIV agents: Probiotic Bacillus subtilis B10 increases Heme oxygenase 2 (HO-2) expression, blocks N-myristoylation of HIV-1 Gag protein, disrupts HIV-1 budding, and restricts HIV-1 production, via upregulation of its target gene, 28/February/2019, 8.09 am

Probiotics function as anti-HIV agents: Probiotic Bacillus subtilis B10 increases Heme oxygenase 2 (HO-2) expression, blocks N-myristoylation of HIV-1 Gag protein, disrupts HIV-1 budding, and restricts HIV-1 production, via upregulation of its target gene, 28/February/2019, 8.09 am https://genomediscovery.org/wp-content/uploads/2019/02/Bacillus-subtilis-B10-acts-as-an-antiviral-agent-against-HIV1-virus-through-induction-of-HO2.jpg 960 720 Dr Boomi's Genom-2-Discovery Center Dr Boomi's Genom-2-Discovery Center https://genomediscovery.org/wp-content/uploads/2019/02/Bacillus-subtilis-B10-acts-as-an-antiviral-agent-against-HIV1-virus-through-induction-of-HO2.jpg February 28, 2019 February 28, 2019

February 28, 2019

Combinatorial therapy for Deafness: A therapeutic mix encompassing 4-Phenylbutyrate (4-PBA), Cholecalciferol, Ajoene and DIM (PCAD) increases the expression of ATG5 (Autophagy-related 5), prevents aggregation of proteins in inclusion bodies, inhibits hair cell degeneration, improves hearing loss via upregulation of its target genes, 28/February/2019, 8.00 am

Combinatorial therapy for Deafness: A therapeutic mix encompassing 4-Phenylbutyrate (4-PBA), Cholecalciferol, Ajoene and DIM (PCAD) increases the expression of ATG5 (Autophagy-related 5), prevents aggregation of proteins in inclusion bodies, inhibits hair cell degeneration, improves hearing loss via upregulation of its target genes, 28/February/2019, 8.00 am https://genomediscovery.org/wp-content/uploads/2019/02/A-pharmaceutical-mixture-encompassing-4Phenylbutyrate-4PBA-Cholecalciferol-and-DIM-protects-against-hearing-loss-through-induction-of-ATG52.jpg 960 720 Dr Boomi's Genom-2-Discovery Center Dr Boomi's Genom-2-Discovery Center https://genomediscovery.org/wp-content/uploads/2019/02/A-pharmaceutical-mixture-encompassing-4Phenylbutyrate-4PBA-Cholecalciferol-and-DIM-protects-against-hearing-loss-through-induction-of-ATG52.jpg February 28, 2019 February 28, 2019

February 28, 2019

Combinatorial anti-cancer therapy targeting CDK4/6 pathway and immune receptors enhances the efficacy of Cancer immunotherapy: A pharmacological mixture encompassing Metformin, Navitoclax/ABT-263, Dasatinib and 2-Deoxy-d-glucose (MNDDG) inhibits the expression of cell cycle protein CDK4/CDK6, increases levels of T-III IFNs, inhibits the proliferation of Treg cells, decreases DNMT1 expression, inhibits the expression of a number of immune evasion molecules, increases antigen presentation and unfolding response, increases Cytotoxic activity of T-cells, decreases tumor burden and increases survival via up-regulation of its target genes, 28/February/2019, 7.39 am

Combinatorial anti-cancer therapy targeting CDK4/6 pathway and immune receptors enhances the efficacy of Cancer immunotherapy: A pharmacological mixture encompassing Metformin, Navitoclax/ABT-263, Dasatinib and 2-Deoxy-d-glucose (MNDDG) inhibits the expression of cell cycle protein CDK4/CDK6, increases levels of T-III IFNs, inhibits the proliferation of Treg cells, decreases DNMT1 expression, inhibits the expression of a number of immune evasion molecules, increases antigen presentation and unfolding response, increases Cytotoxic activity of T-cells, decreases tumor burden and increases survival via up-regulation of its target genes, 28/February/2019, 7.39 am https://genomediscovery.org/wp-content/uploads/2019/02/A-pharmaceutical-mixture-encompassing-Metformin-Navitoclax-Dasatinib-and-2deoxyd-glucose-MNDDG-inhibits-CDK4.6-expression-and-enhances-the-efficacy-of-cancer-immunotherapy.jpg 960 720 Dr Boomi's Genom-2-Discovery Center Dr Boomi's Genom-2-Discovery Center https://genomediscovery.org/wp-content/uploads/2019/02/A-pharmaceutical-mixture-encompassing-Metformin-Navitoclax-Dasatinib-and-2deoxyd-glucose-MNDDG-inhibits-CDK4.6-expression-and-enhances-the-efficacy-of-cancer-immunotherapy.jpg February 28, 2019 February 28, 2019

Probiotics function as anti-HIV agents: Probiotic Bacillus subtilis B10 increases Heme oxygenase 2 (HO-2) expression, blocks N-myristoylation of HIV-1 Gag protein, disrupts HIV-1 budding, and restricts HIV-1 production, via upregulation of its target gene, 28/February/2019, 8.09 am

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