Ideas

March 16, 2019

Repurposing the known anti-hyperglycemic drug Sitagliptin into a stroke medicine: Sitagliptin (brand name: Januvia, Tesavel, Xelevia, and others ), used to bring down high blood glucose levels in Type II diabetes patients, attenuates hippocampal neurons injury, augments regenerative neurogenesis after Ischemic Stroke, and ameliorates stroke damage and neurological deficits, via up-regulation of its target genes BDNF and NAMPT, 16/March/2019, 5.46 am

Introduction: What they say  A recent study from Research Center for Neurobiology and Department of Neurobiology, Xuzhou Medical College, 209 Tongshan Road, Xuzhou, Jiangsu 221004, PR China; […]
March 16, 2019

Ribonucleic acid-based therapy for glaucoma:  LncRNA DGCR5 increases Nmnat1 expression, increases NAD+ levels, improves neuronal dysfunction, and protects against glaucoma,  via down regulation of its target gene, 16/March/2019, 5.30 am

Introduction: What they say A study from the The Jackson Laboratory, Bar Harbor, ME 04609, USA; Department of Ophthalmology, Tufts University of Medicine, Boston, MA 02111, […]
March 15, 2019

Epicatechin-3-gallate(ECG)-based antiviral therapy for chikungunya (CHIKV) and Zika (ZIKV) viruses: Epicatechin-3-gallate(ECG), one of the main components of green tea, increases spermidine/spermine N1-acetyltransferase (SAT) expression, depletes spermidine and Spermine levels, and restricts Chikungunya and Zika viruses replication via upregulation of its target gene, 16/March/2019, 5.23 am

Introduction: What they say A study from the Viral Populations and Pathogenesis Unit, Institut Pasteur, CNRS UMR 3569, 25–28 rue du Dr. Roux, 75724 Paris Cedex […]
March 14, 2019

Molecular therapy for Anti-ageing and Lifespan extension: Sitagliptin (brand name: Januvia), an anti-hyperglycemic drug,  increases CHIP levels, increases monoubiquitylation of insulin receptor (INSR), decreases INSR protein levels and enhances lifespan via down regulation of its target gene, 14/March/2018, 11.12 pm

Introduction: What they say A study from Institute for Cell Biology, University of Bonn, Ulrich-Haberland Str.  Bonn, Germany; and Institute for Genetics and CECAD Research Center, […]
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