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Ideas

July 27, 2018

Awakening the sleeping/cancer-protecting angels in mutant p53-expressing human tumors: Emodin, isolated from Rhubarb and others,  increases the expression of tumor suppressors genes, such as  CADM2, HNF4α, TA-p73, TAp63, p53, and others, induces regression of p53-mutated human tumors, via down regulation of its target gene, 27/July/2018, 10.22 pm

From Significance of the study to Public health relevance:  Given that: (1) cancer suppressor p53 is mutated in more than 50% of human cancers of different […]
July 25, 2018

A sweet way to extend lifespan-too good to be true: Polysaccharide-based therapy for lifespan and healthspan extension: Astragalus polysaccharide, isolated from astragalus membraneous, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian lifespan, 26/July/2018, 12.38 am

What they say?  A study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal […]
July 25, 2018

Unknown function of a known vaccine in the treatment of muscle atrophy and wasting: TB/BCG vaccine,  a tuberculosis vaccine,  increases the expression of FGF19 and its receptor ß-Klotho, phosphorylates ERK1/2 and S6K1, decreases the expression of tumor suppressors  genes, promotes regeneration of muscle cells and hypertrophy of skeletal muscle, and reverses muscular atrophy and wasting, via upregulation of its target gene, 25/July/2018, 11.49 pm

Introduction: What they say A study from Department of Biology, University of Bergen, Bergen, Norway; and Univ-Lyon, CarMeN Laboratory, INSERM 1060, INRA 1397, Université Claude Bernard […]
July 25, 2018

Vaccinate yourself with TB vaccine to lead a pain-free life: TB/BCG vaccine-based activation of the PD-1 pathway for Pain therapy: TB/BCG vaccine, a tuberculosis vaccine,  increases the expression of PD-L1, attenuates acute and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability, via up-regulation of its target gene, 25/July/2018, 11.20 pm

 Introduction: What they say: A recent study, from Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for […]
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