Tuberculosis

March 10, 2020

Published by admin_auro at March 10, 2020

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Repurposing the anti-asthmatic drug Montelukast into an anti-tuberculosis drug: Montelukast (trade name: Singulair) deacetylates RelA/p65, inhibits inflammatory gene expression downstream of RelA/p65, inhibits TB pathogenesis, increases the efficacy of anti-TB drug, and promotes M. tuberculosis clearance via upregulation of its target gene, 10/March/2020, 8.01 am

Introduction: What they say: A study from the Singapore Immunology Network, Agency for Science, Technology and Research, Singapore; and Lee Kong Chian School of Medicine, Nanyang […]

April 8, 2019

Published by admin_auro at April 8, 2019

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Probiotic-based therapy for tuberculosis: Probiotic Lactobacillus fermentum CQPC08 (LFCQPC08) deacetylates RelA/p65, inhibits inflammatory gene expression downstream of RelA/p65, inhibits TB pathogenesis, increases the efficacy of anti-TB drug, and promotes M. tuberculosis clearance via upregulation of its target gene, 8/April/2019, 11.53 pm

Introduction: What they say: A study from the Singapore Immunology Network, Agency for Science, Technology and Research, Singapore; and Lee Kong Chian School of Medicine, Nanyang […]

April 8, 2019

Published by admin_auro at April 8, 2019

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Repurposing the anti-diabetic drug Metformin into an anti-tuberculosis drug: Metformin (trade name: Glucophage, Glumetza, Glucophage XR, Fortamet), the widely used drug in the treatment of TIIDM, deacetylates RelA/p65, inhibits inflammatory gene expression downstream of RelA/p65, inhibits TB pathogenesis, increases the efficacy of anti-TB drug, and promotes M. tuberculosis clearance via upregulation of its target gene, 8/April/2019, 9.50 pm

Introduction: What they say: A study from the Singapore Immunology Network, Agency for Science, Technology and Research, Singapore; and Lee Kong Chian School of Medicine, Nanyang […]

March 28, 2019

Published by admin_auro at March 28, 2019

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Molecular therapy for tuberculosis: AS-2, a derivative of 8-Hydroxyquinoline (8HQ), deacetylates RelA/p65, inhibits inflammatory gene expression downstream of RelA/p65, inhibits TB pathogenesis, increases the efficacy of anti-TB drug, and promotes M. tuberculosis clearance, via upregulation of its target gene, 28/March/2019, 6.51 am

Introduction: What they say: A study from the Singapore Immunology Network, Agency for Science, Technology and Research, Singapore; and Lee Kong Chian School of Medicine, Nanyang […]