Excess consumption of coffee during pregnancy increases the chances of childhood obesity: Caffeine increases the levels of HMGCR,  triglycerides, free cholesterol, and total cholesterol and accelerates the progression of Non-alcoholic fatty liver disease (NAFLD), via up-regulation of its target gene, 14/May/2019, 11.43 pm

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The significance of the study:

Given that: (1)  15-30% of Western populations suffer from Non-alcoholic fatty liver disease (NAFLD), while 6-25% of Asian populations suffer from it; (2) 75 to 100 million people in the US succumb to this disease; (3) obesity and type 2 diabetes are risk factor for the development of NAFLD;  and (4) the global economic cost spent for NAFLD is enormous, there is an urgent need to find: (i) a way to decrease cholesterol deposition in liver; (ii) a cheaper alternative to the existing expensive drugs; (iii) a side-effect-free natural product-based drug; and (iv) a way to cure, not just treat, NAFLD.

Research findings to Therapeutic opportunity:

This study  provides mechanistic insights into how prenatal exposure to excess amount of caffeine or consumption of coffee increases the chances of childhood obesity.

Caffeine, by increasing the expression of its target gene, it may increase the expression of HMGCR (Fig.1). Thereby, it may: (1) increase Triglycerides, free cholesterol, and total cholesterol levels; (2) increase lipid deposition in the liver; (3) increase the chances of childhood obesity; (4) accelerate progression to NAFLD (Fig. 1). Thus, excess consumption of coffee during pregnancy must be avoided (Fig.2). Given the adverse effect of consumption of excess amount of coffee during pregnancy, Gynecologists and medical practitioners may advise pregnant mothers not to consume more than–if it cannot be avoided–3 cups of coffee per day (300mg caffeine/day) .

Figure 1. Mechanistic insights into how prenatal exposure to excess amount of caffeine increases the expression of HMGCR,  cholesterol levels, & triglyceride levels, and accelerates the progression of NAFLD
Figure 2.  Prenatal exposure to excess amount of caffeine or excess consumption of coffee during pregnancy promotes childhood obesity.   Caffeine  increases cholesterol and triglyceride levels and attenuates NAFLD, through up-regulation of HMGCR

 

Details of the research findings:

Idea Proposed/Formulated (with experimental evidence) by:

Dr L Boominathan Ph.D.

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Undisclosed mechanistic information: How does caffeine decrease the expression of HMGCR ?

Amount: $750#

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References:

Web: http://genomediscovery.org or http://newbioideas.com  (6-deoxy-L–mannose).

Citation: Boominathan, L., Excess consumption of coffee during pregnancy increases the chances of childhood obesity: Caffeine increases the levels of HMGCR,  triglycerides, free cholesterol, and total cholesterol and accelerates the progression of Non-alcoholic fatty liver disease (NAFLD), via up-regulation of its target gene, 14/May/2019, 11.43 pm, Genome-2-BioMedicine Discovery center (GBMD), http://genomediscovery.org

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