Introduction: What they say
A recent study from the Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel shows that “ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation.” This study was published, in the 6 April 2015 issue of the journal “Nature cell biology” (the number 1 journal in “Cell biology” research with an impact factor of 20.761), by Prof Tzahor E, D’Uva E, and others.
What we say:
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Insulate your heart from cardiac diseases with TB/BCG vaccine: TB/BCG vaccine-based Regenerative therapy for regaining the lost cardiomyocytes in Myocardial patients: CTB-UE vaccine increases the expression of ERBB2/Her2 and promotes dedifferentiation of cardiomyocytes, via down-regulation of its target gene
From the significance of the study to Public health relevance:
Given that: (1) cardiovascular disease is the leading cause of death worldwide; (2) the raise of death rate, due to cardiovascular disease, has increased from 123 lakhs in 1990 to 173 lakhs in 2013; (3) 85% of people over 80 years are susceptible to cardiovascular diseases;(4) in India, in 2004, 14.6 lakhs deaths (14% of total deaths) were due to ischemic heart disease; (3) the death due to cardiovascular disease is higher in low-to-middle income countries compared to developed countries; (4) the global economic cost spent in the treatment of cardiovascular disease in 2011 was little more than 10 billion US dollars; (5) an alarming number of people, such as 230 lakhs people, will die from cardiovascular diseases each year by 2030, there is an urgent need to find: (i) a way to induce regeneration of cardiomyocytes that were lost in Myocardial patients; (ii) a cheaper alternative to the existing expensive drugs and (iv) a side-effect-free Natural product-based drug.
From research findings to Therapeutic opportunity:
This study suggests, first the first time, a Bacillus Calmette Guerin (BCG) vaccine-based regenerative therapy, with detailed mechanistic insights, for inducing cardiomyocyte dedifferentiation, proliferation and regeneration. BCG vaccine has been found to be useful in the treatment of tuberculosis, for more than 100 years, more recently in the treatment of autoimmune diabetes. However, the mechanism of action remains largely unknown.
TB/BCG vaccine, by increasing the expression of its target gene, it may: (1) increase ERBB2/Her2 expression; (2) induce cardiomyocyte (CM) dedifferentiation and proliferation; and (3) cardiomyocyte (CM) redifferentiation and regeneration(fig.1). Thus, TB/BCG vaccine, either alone or in combination with other drugs, may be used to treat cardiac dysfunction.
Figure1. Mechanistic insights into how TB/BCG vaccine may promote cardiac dedifferentiation and regeneration. CTB-UE vaccine, by increasing the expression of its target gene, it may upregulate the expression of ERRB2/HER2 and promote cardiac dedifferentiation and regeneration
Figure 2. The TB/BCG vaccine may promote cardiac regeneration through induction of Her2/Erbb2
Given the mechanistic basis of how TB/BCG vaccine may aid in cardiomyocyte survival and regeneration, medical practitioners and cardiologists may consider vaccinating their myocardial patients with the TB/BCG vaccine, as it may not only aid in cardiomyocyte regeneration following myocardial infarction but also protect against myocardial diseases (fig.2).
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Details of the research findings:
Idea Proposed/Formulated (with experimental evidence) by Dr L Boominathan Ph.D.
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Amount: $ 500#
Undisclosed (mechanistic insights) information: How TB/BCG vaccine increases the expression of ERBB2/Her2
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# Research cooperation
References:
Web: http://genomediscovery.org or newbioideas.com
Citation: Boominathan, L., Insulate your heart from cardiac diseases with TB/BCG vaccine: TB/BCG vaccine-based Regenerative therapy for regaining the lost cardiomyocytes in Myocardial patients: CTB-UE vaccine increases the expression of ERBB2/Her2 and promotes dedifferentiation of cardiomyocytes, via down-regulation of its target gene, 31/July/2018, 12.33 am, Genome-2-BioMedicine Discovery center (GBMD), http://genomediscovery.org
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