Idea Proposed/Formulated by: Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD.
From research findings to Therapeutic opportunity: This study suggests, for the first time, that Maritoclax (Marinopyrorle A), by suppressing the expression of its target gene p38-α, it can: a) promote cardiomyocyte proliferation & regeneration and function; and b) augment stress resistance against hypoxic stress.
Figure 1. Mechanistic insights into how Maritoclax (Marinopyrorle A) protects against cardiac dysfunction. Maritoclax , by regulating the expression of its target gene, it inhibits the expression of p38alpha. Thereby, it increases NAD+ levels and promotes cardiomyocytes proliferation/surivival/regeneration.
Figure 2. Maritoclax function as a cardioprotective agent through down regulation of p38alpha and up regulation of NAD+ levels.
Thus, pharmacological formulations encompassing “Maritoclax (Marinopyrorle A) or its analogues, either alone or in combination with other drugs” can be used to promote cardiomyocyte proliferation & regeneration; and protect against cardiac dysfunction.
# Research cooperation
Undisclosed information: How does Maritoclax (Marinopyrorle A) suppress the expression of p38-α?
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References:
Citation: Boominathan, L., Marine bacteria aids in heart regeneration and promotes stress resistance: Maritoclax (Marinopyrorle A), found in Marine bacteria, promotes heart regeneration and function and augments stress resistance against hypoxic stress through down regulation of p38-α, 10/January/2020, 7.01 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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