Introduction: What they say
A study from Department of Genetics, Paul F. Glenn Center for the Biology of Aging, Harvard Medical School, Boston, MA, USA; and Department of Pharmacology, School of Medical Sciences, The University of New South Wales, Sydney, New South Wales 2052, Australia shows that “A conserved NAD+ binding pocket that regulates protein-protein interactions during aging.” This research paper was published in the 24 March 2017 issue of the journal “Science” [One of the best research journals in Science with an I.F of 34+] by Prof. David A. Sinclair, Jun Li and others.
What we say:
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Molecular therapy for aging-associated diseases: Lithium, a mood-stabilizing agent used in the treatment of Bipolar disorder, increases NMN/NAD levels, decreases interaction of DBC1 with PARP1, increases PARP1 activity, promotes DNA repair, augments tolerance against radiation, cancer, and aging via down-regulation of its target gene
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What is known?
Prof. David A. Sinclair’s research team has recently shown that: (a) increased levels of NAD+ (found in non-aged tissues) inhibits the interaction the between DBC1 (deleted in breast cancer 1) and PARP1 [poly(adenosine diphosphate–ribose) polymerase]; and promotes DNA repair; (b) decreased levels of NAD+ (found in aged tissues) promotes the interaction between DBC1 and PARP1 and inhibits DNA repair; (c) aged cells/tissues that are low in NAD+ are radiation-sensitive, cancer-prone and prone to accelerated aging; and (d) aging-associated diseases can be reversed by increasing the concentration of NAD+ in aging tissues, suggesting that aging-associated diseases, in part, can be reversed by NAD+ supplementation in older animals.
From research findings to therapeutic opportunity:
This study suggests, for the first time, natural product-based therapy for age-associated diseases.
Lithium, by increasing the expression of its target gene, it may increase the levels of NAMPT and NMN/NAD+. Thereby, it may: (1) increase plasma NMN levels and tissue NAD+ availability; (2) inhibit the interaction between DBC1 and PARP1; (3) augment PARP1’s DNA repair activity; (4) protect against radiation; (5) protect against cancer; and (6) prevent age-associated gene expression pattern and accelerated ageing.
Figure1. Lithium, by increasing NAD+ levels, may suppress aging-associated overall physiological decline, aging-associated diseases and improve health/life span
Thus, pharmacological formulations encompassing “Lithium or its derivatives either alone or in combination with other drugs“ may be used to suppress age-associated overall physiological decline and improve health/life span.[easy_payment currency=”USD”]
Details of the research findings:
Idea Proposed/Formulated (with experimental evidence) by: Dr L Boominathan Ph.D.
Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/
Undisclosed mechanistic information: How Lithium increases the levels of NMN/NAD, inhibits the interaction between DBC1 and PARP1 and promotes DNA repair activity
Amount: $300#
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References:
Citation: Boominathan, L., Molecular therapy for ageing-associated diseases: Lithium, a mood-stabilizing agent used in the treatment of Bipolar disorder, increases NMN/NAD levels, decreases interaction of DBC1 with PARP1, increases PARP1 activity, promotes DNA repair, augments tolerance against radiation, cancer and aging via down-regulation of its target gene, 7/April/2017, 11.08 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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