Introduction: What they say:
A study from the Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA has reported that “miR-34a blocks osteoporosis and bone metastasis by inhibiting osteoclastogenesis and Tgif2.”
This study was published in the June 25, 2014 Nature [I.F >42] by Prof. Wan Y, Krzeszinski and others from the Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
What we say:
On the foundation of this interesting finding, Dr L Boominathan, Director-cum-chief Scientist of GBMD, reports here that: Linalool, one of the main components of Coriander seeds and Lamiaceae among others, inhibits the expression of Tgif2 and suppresses osteoporosis and bone metastasis via up-regulation of its target gene
From Research findings to Therapeutic utility:
Linalool, by up-regulating its target genes, it may suppress the expression of Tgif2. Thereby, it may inhibit the progression of Osteoporosis and bone metastasis (Figs. 1-2).
Figure 1. The chemical structure of Linalool
Figure 2. Coriander leaves plus seeds
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Thus, pharmacological formulations encompassing “Linalool or its analogues either alone or in combination with other compounds that are in use to treat osteoporosis” can be used to inhibit osteoporosis and bone metastasis.
Details of the research findings:
Idea Formulated (with experimental evidence) by: Dr L Boominathan PhD
Undisclosed mechanistic information: How Linalool suppresses the expression of Tgif2
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References:
Citation: Boominathan, L., Molecular therapy for Bone disorders: Linalool, one of the main components of Coriander seeds and Lamiaceae among others, inhibits the expression of Tgif2 and suppresses osteoporosis and bone metastasis via down-regulation of its target gene, 6/March/2017, 12.06 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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