Introduction: What they say
A recent study from From the Department of Pharmacology, Second Military Medical University, Shanghai, China; Department of Science and Education, Shandong Provincial Hospital affiliated to Shandong University, Jinan, China; and Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China (C.-Y.M.) shows that “Regenerative Neurogenesis After Ischemic Stroke Promoted by Nicotinamide Phosphoribosyltransferase-Nicotinamide Adenine Dinucleotide Cascade” This study was published in the June 9 2015 issue of the journal Stroke by Prof Miao CY, Zhao Y, and others.
What we say:
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Molecular therapy for Stroke: 15-deoxy-Δ(12,14)-prostaglandin J2 (15d-PGJ2) augments regenerative neurogenesis after Ischemic Stroke and ameliorates stroke damage and neurological deficits via up regulation of its target gene NAMPT
From research findings to therapeutic opportunity:
This study suggests that 15-deoxy-Δ(12,14)-prostaglandin J2 (15d-PGJ2), by increasing the expression of of its target genes, it may: (1) increase the expression of NAMPT; (2) increase Sirtuins expression; (3) enhance neural stem cells; (4) promote neural functional recovery; (5) activate neuronal survival pathway; (6) promote post-ischemic regeneration after stroke; and (7) attenuate neurological deficits (Fig.1). [easy_payment currency=”USD”]
Figure 1. Mechanistic insights into how 15d-PGJ2 promotes neural functional recovery after stroke. 15d-PGJ2 promotes post-ischemic regeneration via up regulation of its target genes Sirtuins and NAMPT
Together, this study suggests that pharmacological formulations encompassing “15-deoxy-Δ(12,14)-prostaglandin J2 (15d-PGJ2) or its analogues either alone or in combination with other drugs” may be used to treat patients suffering from stroke and neurological deficits.
Details of the idea posted:
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/
Amount: $200#
Undisclosed mechanistic information: How 15-deoxy-Δ(12,14)-prostaglandin J2 (15d-PGJ2) increases the expression of NAMPT and promotes regenerative neurogenesis after ischemic Stroke
For purchase and payment details, you may reach us at info@genomediscovery.org
# Research cooperation
References:
Citation: Boominathan, L., Molecular therapy for Stroke: 15-deoxy-Δ(12,14)-prostaglandin J2 (15d-PGJ2) augments regenerative neurogenesis after Ischemic Stroke and ameliorates stroke damage and neurological deficits via up regulation of its target gene NAMPT, 3/May/2017, 11.32 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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