Significance of the study:
It has been shown earlier that antagonizing angiotensin II type I receptor (AT1R) expression may prolong mammalian life span. Further, it has been shown that disruption of AT1R (AGTR1) gene results in marked prolongation of mammalian lifespan.
From research findings to therapeutic opportunity:
This study suggests, for the first time, that Arecoline, by increasing the expression of its target gene, it may decrease the expression of AT1R.
Figure1. Areca nut tree. Areca nut extract or Arecoline functions as a longevity-promoting agent via down regulation of A1TR
Figure 2. Arecoline inhibits A1TR expression and extends life-span
And, thereby, it may (1) decrease blood pressure; (2) decrease blood sugar levels; (3) decelerate ageing process; and (4) extend the lifespan of an individual. Thus, pharmacological formulations encompassing “Arecoline or its analogues or Arecoline in combination with other natural products” may be used to extend the lifespan of an individual (Figure 1).
Details of the research findings:
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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Undisclosed mechanistic information: How does Arecoline suppress the expression of angiotensin II type I receptor (AT1R)?
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# Research cooperation
References:
Citation: Boominathan, L., Natural product-based Lifespan extension therapy: Arecoline/Areca nut extract prolongs mammalian life span via down regulation of angiotensin II type I receptor (AT1R), 8/February/2017, 9.25 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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