Natural product-based therapy for Diabetic nephropathy (DN): Taxifolin (Tax), isolated from Siberian larch, Cedrus deodara, and others, increases Pyruvate kinase M2 (PKM2) expression, decreases toxic glucose metabolites, mitochondrial dysfunction and apoptosis, augments glycolytic flux and PGC-1α levels, improves metabolic abnormalities, albuminuria, glomerular pathology, and renal dysfunction and alleviates diabetic nephropathy via down-regulation of its target gene, 9/December/2018, 10.13 pm