Natural product-based therapy for Metastatic cancers: (6)-gingerol (6G), one of the main components of Ginger, increases the expression of PDCD4 and inhibits migration, invasion and metastasis of cancer cells via down regulation of its target gene, 17/February/2017, 11.40 am,

Research findings to Therapeutic opportunity: 

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The study presented here suggests that (6)-gingerol (6G), by increasing the expression of its target genes, it may increase the expression of pro-apoptotic protein PDCD4. Thereby, it may inhibit apoptotic resistance, migration, invasion and metastasis of cancer cells. Thus, pharmacological formulations encompassing “(6)-gingerol (6G) or its analogues” may be used to inhibit the progression of invasive tumors.


Details of the research findings

Idea Proposed/Formulated (with experimental evidence) by:

Dr L Boominathan Ph.D.

Undisclosed information: How (6)-gingerol (6G)  increases the expression of metastasis suppressor PDCD4

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References

CitationBoominathan, L., Natural product-based therapy for Metastatic cancers: (6)-gingerol (6G), one of the main components of Ginger, increases the expression of PDCD4 and inhibits migration, invasion and metastasis of cancer cells via down regulation of its target gene, 17/February/2017, 11.40 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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