Introduction: What they say
A recent study from the Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel shows that “ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation.” This study was published in the 6 April 2015 issue of the journal “Nature cell biology” (the number 1 journal in “Cell biology” research with an impact factor of 20.761) by Prof Tzahor E, D’Uva G, and others.
What we say:
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-based therapy for Regenerating the lost cardiomyocytes in Myocardial patients: 2,4,5-trihydroxybenzaldehyde (TDB), found in Geum japonicum and Polygonum cuspidatum (PC), also known as Japanese knotweed, increases the expression of ERBB2/Her2 and promotes dedifferentiation of cardiomyocytes via down regulation of its target gene[easy_payment currency=”USD”]
Public Health Relevance:
Given that: (1) cardiovascular disease is the leading cause of death worldwide; (2) the raise of death rate, due to cardiovascular disease, has increased from 123 lakhs in 1990 to 173 lakhs in 2013; (3) 85% of people over 80 years are susceptible to cardiovascular diseases;(4) in India, in 2004, 14.6 lakhs deaths (14% of total deaths) were due to ischemic heart disease; (3) the death due to cardiovascular disease is higher in low-to-middle income countries compared to developed countries; (4) the global economic cost spent in the treatment of cardiovascular disease in 2011 was little more than 10 billion US dollars; (5) an alarming number of people, such as 230 lakhs people, will die from cardiovascular diseases each year by 2030, there is an urgent need to find: (i) a way to induce regeneration of cardiomyocytes that were lost in Myocardial patients; (ii) a cheaper alternative to the existing expensive drugs; and (iv) a side-effect-free Natural product-based drug.
From research findings to Therapeutic opportunity:
This study suggests a natural product-based cardiac regeneration therapy. 2,4,5-trihydroxybenzaldehyde (TDB), by decreasing the expression of its target gene, it may: (1) increase ERBB2/Her2 expression; (2) induce cardiomyocyte (CM) dedifferentiation and proliferation; and (3) cardiomyocyte (CM) redifferentiation and regeneration.
Figure1. Geum japonicum flower. 2,4,5-trihydroxybenzaldehyde (TDB), isolated from Geum japonicum , may promote cardiac dedifferentiation and regeneration via up-regulation of ERRB2/HER2
Figure2. Polygonum cuspidatum. TDB, which is also found in Polygonum cuspidatum, aids in cardiomyocyte (CM) dedifferentiation
Thus, pharmacological formulations encompassing “2,4,5-trihydroxybenzaldehyde (TDB) or its analogues or TDB plus any of the known compounds that promote cardiac regeneration“ may be used to promote cardiomyocyte regeneration following myocardial infarction.
Idea Proposed/Formulated (with experimental evidence) by:
Dr L Boominathan Ph.D.
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Amount: $ 100
Undisclosed (mechanistic insights) information: How TDB increases the expression of ERBB2/Her2
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References:
Web: http://genomediscovery.org or newbioideas.com
Citation: Boominathan, L., Natural product-based therapy for Regenerating the lost cardiomyocytes in Myocardial patients: 2,4,5-trihydroxybenzaldehyde (TDB), found in Geum japonicum and Polygonum cuspidatum (PC), also known as Japanese knotweed, increases the expression of ERBB2/Her2 and promotes dedifferentiation of cardiomyocytes via down regulation of its target gene, 30/November/2016, 5.54 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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