Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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Citation: Boominathan, Natural-product based therapy for Sepsis: Fiestein, a flavonoid enriched in strawberries, Mangoes and Cucumber, inhibits lung inflammation by inhibiting inflammasome activation pathway, 14/March/2014, 05.59 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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Significance: Uncontrolled/excessive inflammation is the principle cause of tissue damage during sepsis. This study suggests, for the first time, that Fiestein, by increasing the expression of its target gene, it may inhibit the inflammasome activation pathway. Thereby, it may decrease acute lung inflammation during sepsis. Thus, pharmacological formulations encompassing “Fiestein or its analogues” may be used to treat acute lung inflammation during Sepsis.
Undisclosed information: How Fiestein inhibits the inflammasome activation pathway during Sepsis