Introduction: What they say:
A recent study from the Institute of Biophysics, Chinese Academy of Sciences, Beijing, China shows that “Sox2 functions as a sequence-specific DNA sensor in neutrophils to initiate innate immunity against microbial infection.” This study was published in the 2 March 2015 issue of the Journal “Nature Immunology” [the number one journal in immunological research with an impact factor of 24.973] by Drs. Zusen Fan, Xia and others.
What we say:
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Immune enhancement therapy: Long ncRNA-TUG1 (taurine-upregulated gene) increases SOX2 expression and promotes innate immunity against bacterial infection via down-regulation of its target gene.
From Research Findings to Therapeutic Opportunity:
This study suggests, for the first time, Oleanolic acid, by decreasing the expression of its target gene, it may : (1) increase the expression of Sox2; (2) increase the ability of Sox2 to recognize bacterial DNA in cytoplasm; and (3) promote innate immunity against bacterial infection.
Figure 1. Oleanolic acid, isolated from Syzygium S. or Jawa apple, among others, as indicated here, promotes innate immunity against bacterial infections
Figure 2. Oleanolic acid is found in Olea europaea
Figure 3. Oleanolic acid is also found in Prosopis glandulosa
Figure 4. Oleanolic acid
Together, pharmacological formulations encompassing “Oleanolic acid or its analogues or Oleanolic acid in combination with other drugs” may be used to (1) enhance innate immunity against bacterial infection; and (2) promote bacterial resistance (figs. 1-4).
Details of the research findings:
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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Undisclosed mechanistic information: How Oleanolic acid: (1) enhances innate immunity against bacterial infection; and (2) promotes bacterial resistance?
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References:
Citation: Boominathan, L., Natural product-derived Immune enhancement therapy: Oleanolic acid, found in Syzygium S. or Jawa apple and among others, increases SOX2 expression and promotes innate immunity against bacterial infection via down-regulation of its target gene, 3/January/2017, 1.03 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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