What they say: Introduction:
A recent study from the Department of Genetics, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Harvard Medical School, Boston,USA; and Department of Pharmacology, School of Medicine, The University of New South Wales, Australia shows that Sirtuin-2 induces the checkpoint kinase BubR1 to increase lifespan. This study was published in the 1 July 2014 issue of the journal “EMBO” by Prof Sinclair, North BJ, and others.
What we say:
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-derived Lifespan extension therapy: Berberine, found in Phellodendron amurense and Berberis among others, increases life span via up-regulation of its target gene BubR1
What is known?
I have recently published that Berberine may: (i) increase NMN levels, decrease age-associated weight gain, augment energy metabolism, improve physical activity and insulin sensitivity, promote healthy lipid profile, and improve eye function; (ii) increase lifespan by suppressing mTOR pathway through up regulation of its target gene; (iii) activate autophagy and extend lifespan via up regulation of ATG5; and (iv) inhibit senescence and extend lifespan by down regulating the expression of adenylate cyclase 5 (ADCY5).
From Research Findings to Therapeutic Opportunity:
This study suggests a natural product-based life extension therapy. Berberine, by increasing the expression of its target gene, it may increase the expression of BuBR1.
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Thereby, it may: (1) delay diseases of aging; (2) slow down aging; and (3) prolong median life span. Thus, pharmacological formulations encompassing “Berberine or its analogues or Berberine in combination with any of the known anti-ageing drug“ may be used to extend the lifespan of an individual (figs. 1-3).
Figure 1. Berberine, found in Phellodendron amurense and Berberis, as indicated below, may promote mammalian life span via up regulation of BuBR1
Figure 2. Berberine is also found in Berberis
Figure 3. Berberine functions as a longevity promoter
Details on the research findings:
Idea Proposed/Formulated (with experimental evidence) by:
Dr L Boominathan Ph.D.
Amount: $100#
Undisclosed mechanistic information: How Berberine increases the expression of BubR1 and extends mammalian life-span
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# Research cooperation
References:
Web: http://genomediscovery.org or http://newbioideas.com
Citation: Boominathan, L., Natural product-derived Lifespan extension therapy: Berberine, found in Phellodendron amurense and Berberis among others, increases life span via up-regulation of its target gene BubR1, 12/December/2016, 12.00 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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