Introduction: What they say
A study from Faculty of Medicine, Friedrich-Schiller-University, Germany shows that “Epigenetic stress responses induce muscle stem-cell ageing by Hoxa9 developmental signals.” This research paper was published in the 30 November 2016 issue of the journal “Nature” [One of the best research journals in General Science with an I.F of 38+] by Prof.Lenhard Rudolph, Stefan Tümpel, Simon Schwörer and others.
What we say:
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Regenerative therapy for improving muscle repair and strength in the elderly: Succinate, one of the components in Citric acid cycle, extract decreases the expression of HOXA9, increases skeletal muscle regeneration and improves muscle stem cells function and repair via up regulation of its target genes
What is known?
Prof. Lenhard Rudolph’s research team has recently shown that deletion of HOXA9 in mice results in a) down regulation of inhibitors of muscle stem cells function, including Wnt, TGFß, JAK/STAT and senescence signalling; and b) improved muscle stem cells regeneration and function. Conversely, overexpression of HOXA9 has been shown to promote ageing-associated features in muscle stems cells.
From Research findings to Therapeutic opportunity:
This study suggests, for the first time, a natural product-based regenerative therapy for improving muscle strength and repair in the elderly. Succinate, by increasing the expression of its target gene, it may decrease the levels of HOXA9 (fig.1).
Figure 1. Mechanistic insight into how Succinate promotes muscle stem cell regeneration. The Citric acid cycle component Succinate promotes muscle stem cell repair and regeneration via down regulation of HOXA9
Thereby, it may: (1) down regulate inhibitors of muscle stem cells function; and (2) improve of muscle stem cells regeneration and function. Thus, pharmacological formulations encompassing “Succinate or its analogues or Succinate in combination with other drugs” may be used to suppress muscle stem-cell ageing, age-associated physiological decline and improve health span.
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Details of the research findings:
Idea Proposed/Formulated (with experimental evidence) by: Dr L Boominathan Ph.D.
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Undisclosed mechanistic information: How does Succinate decrease the expression of HOXA9?
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References:
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Citation: Boominathan, L., Regenerative therapy for improving muscle repair and strength in the elderly: Succinate, one of the components in Citric acid cycle, extract decreases the expression of HOXA9, increases skeletal muscle regeneration and improves muscle stem cells function and repair via up regulation of its target genes, 7/February/2017, 10.28 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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