What we say:
Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-derived therapy for Allergic rhinitis: Thymoquinone, the most abundant component in Black Cumin– Nigella sativa and in Monarda Fistulosa, inhibits GM-CSF, Interleukin 13 receptor(IL-13)-Rα1, and eotaxin expression, among others, inhibits mucus production and alleviates allergic rhinitis via up regulation of its target gene
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From Significance of the study to Public health relevance:
Given that: (1) in any given year, nearly 20-30% of people are affected by Allergic Rhinitis; (2) most of the medications available today for allergic rhinitis treats only the symptoms, and provide temporary relief; (3) corticosteroid therapy for allergic rhinitis may have its own side effects; (4) the global economic cost spent in the treatment of allergic rhinitis is enormous, there is an urgent need to find: (i) a way to cure allergic rhinitis, without adverse side effects; (ii) a cheaper alternative to the existing expensive medications; (iii) a side-effect-free natural product-based drug; and (iv) a way to cure, not just treat, allergic rhinitis.
From Research findings to Therapeutic opportunity:
This study suggests, for the first time, a natural product based therapy for Allergic Rhinitis. Thymoquinone, by increasing the expression of its target genes, it may: (1) inhibit GM-CSF levels; (2) decrease IL13Rα1 expression; (3) suppress eotaxin expression; and (4) inhibit mucus production (fig 1).
Figure 1. Thymoquinone inhibits the development and progression of Allergic Rhinitis via up regulation of its target gene
Figure 2. Black Cumin– Nigella sativa. Thymoquinone, found in Black Cumin– Nigella sativa, alleviates allergic Rhinitis via up regulation of its target genes
Figure 3. Wild bergamot (Monarda fistulosa). Thymoquinone is also found in Monarda fistulosa.
Thus, pharmacological formulations encompassing “Thymoquinone or its analogues either alone or in combination with other drugs” may be used to control allergic rhinitis.
Details of the research findings:
Idea Proposed/Formulated (with experimental evidence) by: Dr L Boominathan Ph.D.
Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/
Undisclosed mechanistic information: How does Thymoquinone decrease the expression of GM-CSF/L13Ra1/eotaxin to inhibit allergic rhinitis?
Amount: $50
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References:
Web: http://genomediscovery.org or http://newbioideas.com
Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/
Citation: Boominathan, L., Natural product-derived therapy for Allergic rhinitis: Thymoquinone, the most abundant component in Black Cumin– Nigella sativa and in Monarda Fistulosa, inhibits GM-CSF, Interleukin 13 receptor(IL-13)-Rα1, and eotaxin expression, among others, inhibits mucus production and alleviates allergic rhinitis via up regulation of its target gene, 9/April/2017, 11.36 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org